ID A0A2K5EP85_AOTNA Unreviewed; 3064 AA.
AC A0A2K5EP85;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Vacuolar protein sorting 13 homolog A {ECO:0000313|Ensembl:ENSANAP00000035014.1};
GN Name=VPS13A {ECO:0000313|Ensembl:ENSANAP00000035014.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000035014.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000035014.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 37293.ENSANAP00000035014; -.
DR Ensembl; ENSANAT00000053081.1; ENSANAP00000035014.1; ENSANAG00000034677.1.
DR GeneTree; ENSGT00950000183083; -.
DR OMA; PYRVDNF; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
DR GO; GO:0006914; P:autophagy; IEA:Ensembl.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:1905146; P:lysosomal protein catabolic process; IEA:Ensembl.
DR InterPro; IPR015412; Atg2/VPS13_C.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF22; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13A; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF09333; ATG2-VPS13_C; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
DR Pfam; PF06650; VPS13_VAB; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..82
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 105..337
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 535..759
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1833..2342
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2656..2833
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 2838..2922
FT /note="Atg2/VPS13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09333"
FT DOMAIN 2926..3032
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT COILED 67..104
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3064 AA; 348652 MW; D16DBABF9E9EA2AB CRC64;
AVALKNLQIK ENALSQLDVP FKVKVGHIGN LKLTIPWKNL YTLPVEAVLE EIYLLIVPSS
RIKYDPLKEE KQLMEAKQHE LKRIEEAKQK VVDQEQHLPE KQDTFAEKLV TQIIKNLQVK
ISSIHIRYED DITNRDKPLS FGISLQNLSM QTTDQYWVPC LHDETEKLVR KLIRLDNLFA
YWNVKSRMFY LNDYDDSLDN LRNGIVSENI VPEGYDFVFR PISANAKLVM NRRSDFDFSA
PKINLDVELH NIAIEFNKSQ YFSIMELLES VDMMTQNLPY RKFRPDVPLH HHAREWWAYA
IHGVLEVNVC PRLQMWSWNH IRKHRQKMKQ YKELYKKKLT SKKPPGELLV SLEELEKTLD
VFNITIARQQ AEVEVKKAGY KIYKEGVKDP EDNKGWFGWL WSWSEQKTNE QQPDVKPGIL
EEMLTPEEKA LLYEAIGYSE TAVDPTLPKT FEALKFFVHL KSMSIVLREN HQKPELLDIV
IEEFSTLIVQ RPGAQAIKFE TKIDSFHITG LPDNSKKPRL LSSLDDAMSL FQITFEINPI
DETVTQRCVI EAEPLEIIYD ARTVNSIVEF FRPPKEVHLA QLTSATLTKL EEFRHKTATG
LLYIIETQKV LDLKINLKAS YIIVPQDGIF SPTSNLLLLD LGHLKVTSKS RSELPDVKQG
EANLEEIMDI AYDSFDIQLT SIQLLYSRVG DNWREARKLN VSTQHILVPM HFNLELSKAM
VFMDVRMPKF KIFGKLPLIS LRISDKKLQG IMELIESIPK PEPVTEVSAP AKSFQIQTST
SLGTTQISQK IIPLLELPSV SEDDSEEEFF DAPCSPLEEP LQFPTGVKCI RTRKLQKPDC
SVNMTTFKIR FEVPKVLIEF YHLVGDCELP VVEIYVLGLG TEIEIRTYDL KANAFLKEFC
LKCPEYLDEN KKPVYLITTL DNTMEDLLTL EYIKAEKNVP NLKSSYNNVL QLIKVNFSSL
DIHLHTEALL NTINYLNNIL PQSEEKSAPV STTETEDKGD VIKKLALKLS TNEDIITLQI
LAELSCLQIF IQDQKRNISE IKIEGLDSEM IMRPSETEIN AKLRNIIVLD SDITAVYKKV
RIFKINFSFK MVSYMDATAV VFVTKFLYSI FAFIDFSGTG MAATGVKNMA QRSSRMALEF
TSKPQLWSFQ QSPLSEMRLY RSQYINDAYE EALDLLLPLN LEVVVERNLS WEWYQEVPCF
NVNAQLKPME FILSQEDITT IFKTLHGNIQ HEEGGSASPA VTNDQYSVTS GVTTNASHHS
GGSTVVTAAV VEVHSRASPV KTTLNVSFKT DYLTMVLYSP GPKQASFTDV RDPSLKLAEF
KLENILSTLK MYTDDSTFSS FSLKNCILDD KRPHVKKATP RMIGLTVGFD KRDMMDIKYR
KVRDGCVTDA VFQEMYICAS VEFLQTVANV FLEAYTTGTA VETSVQTWTA KEEVPTQESE
KVEINVIIKN PEIVFVADMT KNDAPALVIT TQCEICYKGD LENSTMTAAI KDLQVRACPF
LPVKRKGKIT TVLQPCDLFY QTTQIGTDPQ VIDMSVKSLT LKVSPVIINT MITITSALYT
NKETLPKETA SSTAHLWEKK DTKTLKMWFL EESNETEKTA PTTELVPKGE MIKMNIDSIF
IVLEAGVGHR TVPMLLAKSR FSGEGKNWSS LINLHCQLEL EVHYYNEMFG VWEPLLEPLE
IDQTEDFRPW NLGIKMKKKA KKAIVESDRE EENYKVPEYK TVISLHSKDQ LNITLSKCGL
VMLNNLVKAF TEAATGSSAD FVRDLAPFMI LNSLGLTVSV SPSDSFSVLN IPMAKSYVLK
NEESLNMDYV RTKDNDHFSA MTSLSSKLFF ILLTPVNHST ADKIPLTKVG RRLYTVRHRE
SGVERSIVCQ IDTVEGSKKV TIRSPVQIRN HFSVPLSVYE GDTLLGTVSP ENEFNIPLGS
YRSFLFLKPE DEDYQMCEGI DFEEIIKNDG ALLKKKCRSK NPSKKSFLIN IVPEKDNLTS
LSVYSEDGWD LPYIMHLWPP ILLRNLLPYK IAYYIEGIEN SVFTLSEGHS AQICTVQLDK
ARLHLKLLDY LNHDWKSEYH IKPNQQDISF LNFTCITEME KTDLDIAVHM TYNTGQTVVA
FHSPYWMVNK TGRMLQYKAD GIHRKHPPDY KKPVLFSFQP NHFFNNNKVQ LMVTDSELSD
QFSIDTVGSH GAVKCKGLKM EYQVGVTIDL SSFNITRIVT FTPFYMIKNK SKYHISVAEE
GSGKWLSLDL EQCIPFWPED AASKLLIQVE KSKDPPKRIY FNKQENCILL RLDNELGGII
AEVNLAEHST VITFLDYHDG AATFLLINHT KNELIQYHQS SLSEIEDSLP PGKAVFYTWA
DPGGSRTLKW RCRQSDGDVT QKEDKMMAVD LGTKTIYLVS FFEGLQRIIL FTEDPKVFKV
TYESEKAELA EQEIAVALQD VGISLVNNYT KQEVAYIGIT SSDVVWETKP KKKARWKPMS
VKHTEKLERE FKEYTESSPS EDKVVELDTN IPVRLTPTGH NMKILQPHAI ALRRNYLPAL
KMEYNTSAHQ SSFRVQIYRI QIQNQIHGAV FPFVFYPVKP PKSVTMDSAP KPFTDVSIVM
RSAGHSQISR IKYFKVLIQE MDLRLDLGFV YALTDLMTEA EVTENTEVEL FHKDIEAFQE
EYKTVSLVDQ SQVSLYEYFH ISPIKLHLSV SLSSGREEAK DSKQNGGLIP VHSLNLLLKS
IGATLTDVQD VVFKLAFFEL NYQFHTTSDL QSEVIRHYSK QAIKQMYVLI LGLDVLGNPF
GLIREFSEGV EAFFYEPYQG AIQGPEEFVE GMALGLKALV GGAVGGLAGA ASKITGAMAK
GVAAITMDED YQQKRREAMN KQPAGFREGI TRGGKGLVSG FVSGITGIVT KPIKGAQKEG
AAGFFKGVGK GLVGAVARPT GGIIDMASST FQGIKRATET SEVESLRPPR FFNEDGVIRP
YRLRDGTGNQ MLQVMENGRF AKYKYFTHVM INKTDMLMIT RRGVLFVTKG TFGQLTCEWQ
YSFDEFTKEP FIVHGRRLRI EAKERVKSVF HAREFGKIIN FRTPEDARWI LTKLEEAREP
SPSL
//