ID A0A2K5ERU0_AOTNA Unreviewed; 943 AA.
AC A0A2K5ERU0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Sorting nexin 14 {ECO:0000313|Ensembl:ENSANAP00000035931.1};
GN Name=SNX14 {ECO:0000313|Ensembl:ENSANAP00000035931.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000035931.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000035931.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR AlphaFoldDB; A0A2K5ERU0; -.
DR Ensembl; ENSANAT00000054001.1; ENSANAP00000035931.1; ENSANAG00000035311.1.
DR GeneTree; ENSGT00950000182856; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR CDD; cd06877; PX_SNX14; 1.
DR CDD; cd08722; RGS_SNX14; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037436; SNX14_PX.
DR InterPro; IPR037892; SNX14_RGS.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 51..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 136..308
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 340..472
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 574..694
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 943 AA; 109923 MW; EDD2153BB99FB4A2 CRC64;
MVPWVRTIGE KLKQRLRLDV GREICRQYPL FCFLKLELCL SFGSNDYFYL FLRYLHVLMI
FWSFVAGVVT FYCSLGPDSL LPNIFFTIKY KPKQLGLQEL FPQGHSCAVC GKVKCKRHRP
SLLLENYQPW LDLKISSKVD ASLSEVTDLI LTEIVKCLDV TDDESFVDEL RITLRFFASV
LIRRIHKVDI PSIITKKLLK AAMKHIEVIV KARQKVKNTE FLQQAALEEY GPELHVALRS
RRDELHYLRK LTELLFPYIL PPKATDCRSL TLLIREILSG SVFLPSLDFL ADPDTVNHLL
IIFIDDSPPE KATEPASPLV PFLQKFAEPR NKKPSVLKLE LKQIREQQDL LFRFMNFLKQ
EGAVHVLQFC LTVEEFNDRI LRPELSNDEM LSLHEELQKI YKTYCLDESI DKIRFDPFIV
EEIQRIAEGP YIDVVKLQTM RCLFEAYEHV LSLLENVFTP MFCHSDEYFR QLLRGAESPT
RNSKFNRGSL SLDDFRNTQK RGESFGISRI GSKIKGVFKS TTMEGAMLPN YGLAEGEDDF
IEEGIVVMED DSPVEAVSTP NTPRNLAAWK ISIPYVDFFE DPSSERKEKK ERIPVFCIDV
ERNDRRAVGH EPEHWSVYRR YLEFYVLESK LTEFHGTFPD AQLPSKRIIG PKNYEFLKSK
REEFQEYLQK LLQHPELSNS QLLADFLSPN GGETQFHDKI LPDVNLGKII KSVPGKLMKE
KGQHLEPFIM NFINSCESPK PKPSRPELTI LSPTSENNKK LFNDLFKNNA NRAENTERKQ
NQNYFMEVMT VEGVYDYLMY VGRVVFQVPD WLHHLLMGTR ILFKNTLEMY TDYYLQCKLE
QLFQEHRLVS LITLLRDAIF CENTEPRSLQ DKQKGAKQTF EEMMNYIPDL LVKCIGEETK
YESIRLLFDG LQQPVLNKQL TYVLLDIVIQ ELFPELNKVT EKQ
//
