ID A0A2K5ESW8_AOTNA Unreviewed; 1163 AA.
AC A0A2K5ESW8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=RAS protein activator like 2 {ECO:0000313|Ensembl:ENSANAP00000036314.1};
GN Name=RASAL2 {ECO:0000313|Ensembl:ENSANAP00000036314.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000036314.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000036314.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5ESW8; -.
DR Ensembl; ENSANAT00000054385.1; ENSANAP00000036314.1; ENSANAG00000035643.1.
DR GeneTree; ENSGT00940000157702; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF52; RAS GTPASE-ACTIVATING PROTEIN NGAP; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT DOMAIN 180..298
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 358..550
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 32..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 827..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1140..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 990..1076
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 45..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..878
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..977
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1163 AA; 131278 MW; 15C558DF7FB0741E CRC64;
MEKFSGWRMS LLSPGDVAEW LDSSTEEEKS LLSFLEVPAE RSPRRRSISG TSTSEKPNSM
DTANTSPFKV PGFFSKRLKG SIKRTKSQSK LDRNTSFRLP SLRNTDDRSR GLPKLKESRS
HESLLSPCSA VECLDLGRGE PVSVKPLHSS ILGQDFCFEV TYLSGSKCFS CNSASERDKW
MENLRRTVQP NKDNCRRAEN VLRLWIIEAK DLAPKKKYFC ELCLDDTLFA RTTSKTKADN
IFWGEHFEFF SLPPLHSITV HIYKDVEKKK KKDKNNYVGL VNIPTASVTG RQFVEKWYPV
STPTPNKGKT GGPSIRIKSR FQTITILPME QYKEFAEFVT SNYTMLCSVL EPVISVRNKE
ELACALVHIL QSTGRAKDFL TDLVMSEVDR CGEHDVLIFR ENTIATKSIE EYLKLVGQQY
LHDALGEFIK ALYESDENCE VDPSKCSSSE LIDHQSNLKM CCELAFCKII NSYCVFPREL
KEVFASWKQQ CLNHGKQDIS ERLISASLFL RFLCPAIMSP SLFNLMQEYP DDRTSRTLTL
IAKVIQNLAN FAKFGNKEEY MAFMNDFLEH EWGGMKRFLL EISNPDTISN TPGFDGYIDL
GRELSVLHSL LWEVVSQLDK ATVAKLGPLP RVLADITKSL TNPTPIQQQL RRFTEHNSSP
NVSGSLSSGL QKIFEDPTDS DLHKLKSPSQ DNTDSYFRGK TLLLVQQASS QSMTYSEKDE
KESSLPNGRS ISLMDLQDTH AAQVEHASVM LDVPIRLTGS QLSITQVASI KQLRETQSTP
QSAPQVRRPL HPALNQPGGL QPLSFQNPVY HLNNPIPAMP KASIDSSLEN LSTASSRSQS
NSEDFKLSGP SNSSMEDFTK RSTQSEDFSR RHTVPDRHIP LALPRQNSTG QAQIRKVDQA
GLGARAKAPP SLPHSASLRS TGSMSVASAA LVAEPVQNGS RSRQQSSSSR ESPVPKVRAI
QRQQTQQVQS PVDSATMSPV ERTAAWVLNN GQYEEDVEET EQNQDEAKHA EKYEQEITKL
KERLRVSSRR LEEYERRLLV QEQQMQKLLL EYKARLEDSE ERLRRQQEEK DSQMKSIISR
LMAVEEELKK DHAEMQAVID AKQKIIDAQE KRIVSLDSAN TRLMSALTQV KERYSMQVRN
GISPTNPTKL SITENGEFKN SSC
//
