ID A0A2K5EVM7_AOTNA Unreviewed; 148 AA.
AC A0A2K5EVM7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Receptor activity-modifying protein 1 {ECO:0000256|ARBA:ARBA00041071};
GN Name=RAMP1 {ECO:0000313|Ensembl:ENSANAP00000037251.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000037251.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000037251.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Transports the calcitonin gene-related peptide type 1
CC receptor (CALCRL) to the plasma membrane. Acts as a receptor for
CC calcitonin-gene-related peptide (CGRP) together with CALCRL.
CC {ECO:0000256|ARBA:ARBA00037503}.
CC -!- SUBUNIT: Heterodimer of CALCRL and RAMP1.
CC {ECO:0000256|ARBA:ARBA00038839}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the RAMP family.
CC {ECO:0000256|ARBA:ARBA00007087}.
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DR RefSeq; XP_012289528.1; XM_012434105.1.
DR AlphaFoldDB; A0A2K5EVM7; -.
DR STRING; 37293.ENSANAP00000037251; -.
DR Ensembl; ENSANAT00000055333.1; ENSANAP00000037251.1; ENSANAG00000036130.1.
DR GeneID; 105704729; -.
DR CTD; 10267; -.
DR GeneTree; ENSGT00940000159224; -.
DR OMA; CYWPNRM; -.
DR OrthoDB; 4199890at2759; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:1990406; C:CGRP receptor complex; IEA:Ensembl.
DR GO; GO:0097643; F:amylin receptor activity; IEA:Ensembl.
DR GO; GO:1990407; F:calcitonin gene-related peptide binding; IEA:Ensembl.
DR GO; GO:0001635; F:calcitonin gene-related peptide receptor activity; IEA:Ensembl.
DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0097647; P:amylin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:1990408; P:calcitonin gene-related peptide receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0006816; P:calcium ion transport; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0060050; P:positive regulation of protein glycosylation; IEA:Ensembl.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.150.510; Receptor activity modifying family; 1.
DR InterPro; IPR006985; RAMP.
DR InterPro; IPR038126; RAMP_sf.
DR PANTHER; PTHR14076; RECEPTOR ACTIVITY MODIFYING PROTEIN RAMP; 1.
DR PANTHER; PTHR14076:SF3; RECEPTOR ACTIVITY-MODIFYING PROTEIN 1; 1.
DR Pfam; PF04901; RAMP; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..148
FT /note="Receptor activity-modifying protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014436885"
FT TRANSMEM 118..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 148 AA; 16837 MW; D11085FEBE579982 CRC64;
MARALCRLPR RCLWLLLAHH LFMATACQEA DYGALLQKLC LTQFQVDMEA VGETLWCDWG
KTIRSYGDLA DCTWQVTEKL GCFWPNAEVD RFFLAVHGHY FRSCPVSGRA MRDPPSSILY
PFVVVPIVVT LLVTALVVWQ SKRTEGIV
//
