ID A0A2K5EX32_AOTNA Unreviewed; 2802 AA.
AC A0A2K5EX32;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=LPS responsive beige-like anchor protein {ECO:0000313|Ensembl:ENSANAP00000037792.1};
GN Name=LRBA {ECO:0000313|Ensembl:ENSANAP00000037792.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000037792.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000037792.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSANAT00000055875.1; ENSANAP00000037792.1; ENSANAG00000036178.1.
DR GeneTree; ENSGT00940000154778; -.
DR OMA; NERGPWG; -.
DR Proteomes; UP000233020; Unplaced.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF64; LIPOPOLYSACCHARIDE-RESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF06469; DUF1088; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 2044..2152
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2171..2460
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1160..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1753..1782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1163..1194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2802 AA; 312799 MW; 21578A6CFCA61F9B CRC64;
MASEDNRVPS PSPTGDDEGG GGREETPTEG GALSLKPGLP IRGIRMKFAV LTGLVEVGEV
SNRDIVETVF NLLVGGQFDL EMNFIIQEGE SINCMVDLLE KCDITCQAEV WSVFTAILKK
SIRNLQVCTE VGLVEKVLGK IEKVDNMIAD LLVDMLGVLA SYNLTVRELK LFFSKLQGDK
GQWPPHAGKL LSVLKHMPQK YGPDAFFNFP GKSAAAIALP PIAKWPYQNG FTFHTWLRMD
PVNNINVDKD KPYLYCFRTS KGLGYSAHFV GGCLIITSIK SKGKGFQHCV KFDFKPQKWY
MVTIVHIYNR WKNSELRCYV NGELASYGEI TWFVNTSDTF DKCFLGSSET ADANRVFCGQ
MTAVYLFSEA LNAAQIFAIY QLGLGYKGTF KFKAESDLFL AEHHKLLLYD GKLSNAIAFT
YNPRATDAQL CLESSPKDNS SIFVHSPHAL MLQDVKAVLT HSIQSAMHSI GGVQVLFPLF
AQLDYRQYLS DEVDLTICST LLAFIMELLK NSIAMQEQML ACKGFLVIGY SLEKSSKSHV
SRAVLELCLA FSKYLSNLQN GMPLLKQLCD HILLNPAIWI HTPAKVQLML YTYLSTEFIG
TVNIYNTIRR VGTVLLIMHT LKYYYWAVNP QDRSGITPKG LDGPRPNQKE ILSLRAFLLM
FIKQLVMKDS GVKEDELQAI LNYLLTIHED DNLMDVLQLL VALMSEHPNS MIPAFDQRNG
LRVIYKLLAS KSEGIRVQAL KAMGYFLKHL APKRKAEVML GHGLFSLLAE RLMLQTNLIT
MTTYNVLFEI LIEQIGTQVI HKQHPDPDSS VKIQNPQILK VIATLLRNSP QCSESMEVRR
AFLSDMIKLF NNSRENRRSL LQCSVWQEWM LSLCYFNPKN SDEQKITEMV YAIFRILLYH
AVKYEWGGWR VWVDTLSITH SKVTFEIHKE NLANIFREQQ GKVDEEIGPC SSTSVEAASV
IRRDVNVSAR YQQSDRKDSP VYPHFTNGNE NSSIEKTCLL ESASNIELQT TNTSNTSYEE
MKAEQENQEL PDEGMLEETL TNEIRNAGDL EVSSDIVEAV TVSSNSFITT GKDSMTVSEV
TASISSPSEE DVSEIPEFLD KSIVEEEEDD DYVELKVEGS PTEEASLPIE LQDNSLSPAA
SEASEKLDMF GNDHKLICQE GKPVSEKQTN TETQDSKDSG IQTMTASGSS ARSPETIVSQ
RAVESDLGQM LEEGRKATNL TRETKLISDY HGNASEVSAS SEQKIAKLDV SSVAADTERL
ELKASTNVEA PQPHQHVLEM SRQPEQPGQG IAPDAVNGQR RDSRSTMFRI PEFNWSQMHQ
RLLTDLLFSI ETDIQMWRSH STKTVMDFVN SSDNVIFVHN TIHLISQVMD NMVMACGGIL
PLLSAATSAT HELENIEPTQ GLSIEASVTF LQRLISLVDV LIFASSLGFT EIEAEKNMSS
GGILRQCLRL VCAVAVRNCL ECQQHSQLKT RGNKALKTIH SLIPLGKSAA KSPVDIVTGG
ISPVRDLDRL LQDMDINRLR AVVFRDIEDS KQAQFLALAV VYFISVLMVS KYRDILEPQN
ERHSQTLTET GSENGNVSLS GKFAFSIPLY QSSNKCGKSA KKKXXXXGLG SHVEVTPHTA
PPGVSAGPDA ISEVLSTLSL EVSKSPETKN DRGNELDTKA TPSVSVSKNV NVKDILRSLV
NIPPDGVTVD PALLPPACLG ALGDLSVEQT VQFRSFDRSV IVATKKSAVS PCTLTTSIPT
NAVSVVSSVD SAQASDVGGE SPGSRSSNAK LPSVPTVDSV SQDPVSNMSI TERLEHALEK
AAPLLREIFV DFAPFLSRTL LGSHGQELLI EGTSNDISSA IFEWQNSIQK NAGLAFIELV
NEGRLLSQTM KDHLVRVANE AEFILSRQRA EDIHRHAEFE SLCAQYSADK REDEKMCDHL
IRAAKYRDHV TATQLIQKII NILTDKHGAW GNSALSRPRE FWRLDYWEDD LRRRRRFVRN
PLGSTHPEAT LKTAVEHATD EDILAKGKQS IKSQALGNQN SENEIFLEGD DDTLSSVDEK
DLENLAGAVS LSTPAQLVAP SVVVKGTLSV TSSELYFEVD EEDPNFKKID PKILAYTEGL
HGKWLFTEIR SIFSRRYLLQ NTALEIFMAN RVAVMFNFPD PAIVKKVVNC LPRVGVGTSF
GLPQTRRISL ASPRQLFKAS NMTQRWQHRE ISNFEYLMFL NTIAGRSYND LNQYPVFPWV
ITNYESEELD LTLPTNFRDL SKPIGALNPK RAAFFAERYE SWEDDQVPKF HYGTHYSTAS
FVLAWLLRIE PFTTYFLNLQ GGKFDHADRT FSSISRAWRN SQRDTSDIKE LIPEFYYLPE
MFVNFNNYNL GVMDDGTVVS DVELPPWAKT SEEFVHINRL ALESEFVSCQ LHQWIDLIFG
YKQQGPEAVR ALNVFYYLTY EGAVNLNSIT DPVLREAVEA QIRSFGQTPS QLLIEPHPPR
GSAMQVVSAI FSLLISCLSF RSSTHILPAI GYVFLLEFSI ITLKDQLFFL PILTASNTGM
HRRQITDLLD QSIQVHSQCF VITSDNRYIL VCGFWDKSFR VYSTDTGKLI QVVFGHWDVV
TCLARSESYI GGNCYILSGS RDATLLLWYW NGKCSGIGDN PGSETAAPRA ILTGHDYGIT
CAAVCAELGL VLSGSQEGPC LIHSMNGDLL RTLEGPENCL KPKLIQASRE GHCVIFYENG
LFCTFSVNGK LQATMETDDN IRAIQLSRDG QYLLTGGDSG VVVVRQVSDL KQLFAYPGCD
AGIRAMALSY DQRCIISGMA SGSIVLFYND FNRWHHEYQT RY
//
