ID A0A2K5EX69_AOTNA Unreviewed; 872 AA.
AC A0A2K5EX69;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000037827.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000037827.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
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DR AlphaFoldDB; A0A2K5EX69; -.
DR Ensembl; ENSANAT00000055911.1; ENSANAP00000037827.1; ENSANAG00000036378.1.
DR GeneTree; ENSGT00950000183008; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd11569; FAT-like_BCAR1_C; 1.
DR CDD; cd12001; SH3_BCAR1; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR Gene3D; 1.20.120.830; Serine-rich domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR046976; BCAR1_C.
DR InterPro; IPR035745; BCAR1_SH3.
DR InterPro; IPR021901; CAS_C.
DR InterPro; IPR037362; CAS_fam.
DR InterPro; IPR014928; Serine_rich_dom.
DR InterPro; IPR038319; Serine_rich_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10654:SF15; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1; 1.
DR PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR Pfam; PF12026; CAS_C; 1.
DR Pfam; PF08824; Serine_rich; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..63
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 67..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..92
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 872 AA; 93674 MW; 3C4063E6004E075C CRC64;
MENVLAKALY DNVAESPDEL SFRKGDIMTV LEQDTQGLDG WWLCSLHGRQ GIVPGNRLKI
LVGMYDKKPA GPGPGPPAAP AQPQPGLPQS LHAPAPPTSQ YTPMLPATYQ PQPDSVYLVP
TPSKTPQGLY QAPGPSPQFQ SPPAKQTSTF SKQTPHHPFP SPATDLYQVP PGPGGPAQDI
YQVPPSAGMG HDIYQVPPSM DTRSWEGTKP PAKVVVPTRV GQGYVYEAAQ PEQDEYDIPR
HLLAPGPQDI YDVPPVRGLL PSQYGQEVYD TPPMAVKGPN GRAPLLEVYD VPPSVEKGLP
LSSHHAVYDV PPSVSKDVPD GPLLREETYD VPPAFAKAKP FDPTRTPLVL ASPPLDSPPA
EDVYDVPPPA PDLYDVPPGL RRPGPGTLYD VPRERVLPPE VADGGAADDG VYAVPPPAER
EAPVDGKRLS ASSTGSTRSS QSASSLEVAG PGREPLELEV AVEALARLQQ GVSATVAHLL
DLAGSTGGTR SWRSTPEPQE PLVQELRAAV AAVQSAVHEL LEFARSAVGN AAHTSDRALH
AKLSRQLQKM EDVHQTLVAH GQALDTGRGG PGATPEDLDR LVACSRAVPE DAKQLASFLH
GNASLLFRRT KAPAPGPEGG GTLHPNPTDK ASSIQSRPLP SPPKFTSQDS PDGQYENSEG
GWMEDYDYVH LQGKEEFEKT QKELLEKGSI TRQGKSQLEL QQLKQFERLE QEVSRPIDHD
LANWTPAQPL APGRTGSLGP SDRQLLLFYL EQCEANLTTL TNAVDAFFTA VATNQPPKIF
VAHSKFVILS AHKLVFIGDT LSRQAKAADV RSQVTHYSNL LCDLLRGIVA TTKAAALQYP
SPSAAQDMVE RVKELGHSTQ QFRRVLGQLA AA
//
