ID A0A2K5EZX7_AOTNA Unreviewed; 431 AA.
AC A0A2K5EZX7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=TNF receptor superfamily member 10a {ECO:0000313|Ensembl:ENSANAP00000038774.1};
GN Name=TNFRSF10A {ECO:0000313|Ensembl:ENSANAP00000038774.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000038774.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000038774.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter
CC molecule FADD recruits caspase-8 to the activated receptor. The
CC resulting death-inducing signaling complex (DISC) performs caspase-8
CC proteolytic activation which initiates the subsequent cascade of
CC caspases (aspartate-specific cysteine proteases) mediating apoptosis.
CC {ECO:0000256|PIRNR:PIRNR037867}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PIRNR:PIRNR037867,
CC ECO:0000256|PROSITE-ProRule:PRU00206}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K5EZX7; -.
DR STRING; 37293.ENSANAP00000038774; -.
DR Ensembl; ENSANAT00000056869.1; ENSANAP00000038774.1; ENSANAG00000036835.1.
DR GeneTree; ENSGT00940000162957; -.
DR OMA; CAKCKPG; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0045569; F:TRAIL binding; IEA:UniProtKB-UniRule.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0036462; P:TRAIL-activated apoptotic signaling pathway; IEA:UniProtKB-UniRule.
DR CDD; cd08315; Death_TRAILR_DR4_DR5; 1.
DR CDD; cd10580; TNFRSF10; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR020465; TNFR_10.
DR InterPro; IPR034024; TNFRSF10_N.
DR InterPro; IPR034029; TNFRSF10A/B_death.
DR PANTHER; PTHR46330:SF16; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A; 1.
DR PANTHER; PTHR46330; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PIRSF; PIRSF037867; CD261_antigen; 1.
DR PRINTS; PR01956; TNFACTORR10.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00208; TNFR; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 3.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703, ECO:0000256|PIRNR:PIRNR037867};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00206}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037867};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037867};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR037867};
KW Transmembrane helix {ECO:0000256|PIRNR:PIRNR037867}.
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR037867"
FT TRANSMEM 209..232
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR037867"
FT REPEAT 113..157
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 113..157
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 158..198
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 158..198
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 346..415
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 136..149
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 139..157
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 180..198
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 431 AA; 46885 MW; 6BFD6187EB921EC4 CRC64;
TATPSIARGS SASRRDGGRG ALPTPMRQQG PCAEAPSRAR AGRAPGPRRA REARPGLRVS
QTFFVFVIVI GVLLWAVPAS AGDDQLPASQ QWKHSPLGEV CPAESYQSEH SGDCNQYTAG
GGYTNASNNL PSCCPCRVCK SDEEELSPCT TTRNRVCQCK PGTFREEDSP EMCRKCSIQC
LSGTVPVSNC TPDSDIKCEE KSGNGHDVWV ILLAIVALLL FVTMLIICWC ICSGCGRDSE
CMDSVCSFCS CPLRGPEAKD NDHNEILSNA DSLSTFASEE PMESQEPTDL TDVIVQSPGE
AQSLLRPAED KGSQRTRLLV LPNGADPTET LRQCFHHFTD NVPFNSWDQL MRQLDLTENE
ICVARAEAAG PRDALYVMLT KWVNKTGRNA SIHALLNALE MLGERHARER IQDLLVNSGK
FIYQEDGTGA A
//
