ID   A0A2K5F0S7_AOTNA        Unreviewed;       939 AA.
AC   A0A2K5F0S7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO3 {ECO:0000313|Ensembl:ENSANAP00000039043.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000039043.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000039043.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   AlphaFoldDB; A0A2K5F0S7; -.
DR   Ensembl; ENSANAT00000057140.1; ENSANAP00000039043.1; ENSANAG00000036939.1.
DR   GeneTree; ENSGT00940000156257; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:UniProt.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF16; ANOCTAMIN-3; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        387..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        464..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        536..553
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        559..579
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        600..622
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        716..739
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        767..791
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        864..893
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          149..373
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          376..907
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   939 AA;  109727 MW;  4BDB168B9C5BF902 CRC64;
     GARHSGSCMN ISKSEITKET SLKPSRRSLP CLAQSYAYSK SLSQSTSLFQ STESESQAPT
     SITLISTDKA EQVNTEENQN DSMLKCSFAD LSDFCLALGK DKDYTDESEH ATYDRSRLIN
     DFVTKDKSEF KTKLSKNDMN YIASSGPLFK DGKKRIDYIL VYRKTNIQYD KRNTFEKNLR
     AEGLMLEKEP AIASPDIMFI KIHIPWDTLC KYAERLNIRM PFRKKCYYTD GRSKSMGRMQ
     TYFRRIKNWM AHNPMVLDKS AFPDLEESDC YTGPFSRARI HHFIINNKDT FFSNATRSRI
     VYHMLERTKY ENGISKVGIR KLINNGSYIA AFPPHEGAYK SSQPIKTHGP QNNRHLLYER
     WARWGMWYKH QPLDLIRLYF GEKIGLYFAW LGWYTGMLIP AAIVGLCVFF YGLFTMNKSQ
     VSQEICKATE VFMCPLCDKN CSLQRLNDSC IYAKVTYLFD NGGTVFFAIF MAIWATVFLE
     FWKRRRSILT YTWDLIEWEE EEETLRPQFE AKYYKMEIVN PITGKPEPHQ PSSDKISLVI
     TAVFGVVFAS FKWNFIKQYW QFATSAAAVC INFIIIMLLN LVKYPRTESE WENSFALKMF
     LFQFVNLNSS IFYIAFFLGR FVGHPGKYNK LFDRWRLEEC HPSGCLIDLC LQMGVIMFLK
     QIWNNFMELG YPLIQNWWSR HKIKRGIHDA SIPQWENDWN LQPMNLHGLM DEYLEMVLQF
     GFTTIFVAAF PLAPLLALLN NIIEIRLDAY KFVTQWRRPL PARATDIGIW LGILEGIGIL
     AVITNAFVIA ITSDYIPRFV YEYKYGPCAN HVEQSENCLK GYVNNSLSFF DLSELGMGKS
     GYCRYRDYRG PPWSSKPYEF TLQYWHILAA RLAFIIVFEH LVFGIKSFIA YLIPDVPKGL
     HERIRREKYL VQEMMYEAEL EHLQQQRRKS GQPVHHEWP
//