ID A0A2K5F179_AOTNA Unreviewed; 420 AA.
AC A0A2K5F179;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=G protein subunit alpha L {ECO:0000313|Ensembl:ENSANAP00000039185.1};
GN Name=GNAL {ECO:0000313|Ensembl:ENSANAP00000039185.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000039185.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000039185.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(s) subfamily.
CC {ECO:0000256|ARBA:ARBA00007172}.
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DR AlphaFoldDB; A0A2K5F179; -.
DR STRING; 37293.ENSANAP00000039185; -.
DR Ensembl; ENSANAT00000057283.1; ENSANAP00000039185.1; ENSANAG00000037012.1.
DR GeneTree; ENSGT00940000155271; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000367; Gprotein_alpha_S.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF233; GUANINE NUCLEOTIDE-BINDING PROTEIN G(OLF) SUBUNIT ALPHA; 1.
DR Pfam; PF00503; G-alpha; 2.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00443; GPROTEINAS.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 12..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 48183 MW; 11C47DAFD355520F CRC64;
MGLCYSLRPL LFGGPGDDPC AASEPRVEDA QPAPAPAPAL VLVRAAAEDT ARTPLPRGGG
GSLACARPKE AKQKEKRRRT EQLSAEEREA AKEARKVSRG IDRILREQKR DLQQTHRLLL
LGAGESGKST IVKQMRILHV NGFNPEEKKQ KILDIRKNVK DAIVTIVSAM STIIPPVPLA
NPENQFRSDY IKSIAPITDF EYSQEFFDHV KKLWDDEGVK ACFERSNEYQ LIDCAQYFLE
RIDSVSLVDY TPTDQDLLRC RVLTSGIFET RFQVDKVNFH MFDVGGQRDE RRKWIQCFNV
YVKFVYLFLF FRWLRTISII LFLNKQDMLA EKVLAGKSKI EDYFPEYANY TVPEDAPTLA
RVSVSTRSRL FLRISTATGD GKHYCYPHFT CAVDTENIRR VFNDCRDIIQ RMHLKQYELL
//
