ID   A0A2K5F277_AOTNA        Unreviewed;       840 AA.
AC   A0A2K5F277;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO1 {ECO:0000313|Ensembl:ENSANAP00000039574.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000039574.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000039574.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU280814}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K5F277; -.
DR   Ensembl; ENSANAT00000057675.1; ENSANAP00000039574.1; ENSANAG00000037157.1.
DR   GeneTree; ENSGT00940000157182; -.
DR   OMA; WKQRVRT; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:UniProt.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF13; ANOCTAMIN-1; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        215..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        292..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        370..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        416..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        460..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        586..609
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          3..201
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          204..780
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   REGION          806..829
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   840 AA;  97653 MW;  2902CB705E73446B CRC64;
     VDYHEDDKRF RREEYEGNLL EAGLELERDE DTKIHGVGFV KIHAPWNVLC REAEFLKLKM
     PTKKMYHINE TRGLLKKISS VLQKITDPIQ PKVADHRPQT MKILSYPFSR EKQHLFDLSD
     KDSFFDSKTR STIVYEILKR TTCTKAKYSM GITSLLANGV YAAAYPLHDG DYEGENVEFN
     DRKLLYEEWA RYGVFYKYQP IDLVRKYFGE KIGLYFAWLG VYTQMLIPAS VVGIIVFLYG
     CATMDENIPS MEMCDQRYNI TMCPLCDKTC SYWKMSSACA TARASHLFDN PATVFFSVFM
     ALWAATFMEH WKRKQMRLNY HWDLTGFEEE EDHPRAEYEA RVLEKSLKKE SKNKETDKVK
     LTWRDRFPAY LTNMVSIIFM IAVTFAIVLG VIIYRISMAA ALAMNSSPSV RSNIRVTVTA
     TAVIINLVVI ILLDEVYGCI ARWLTKIEVP KTEKSFEERL IFKAFLLKFV NSYTPIFYVA
     FFKGRFVGRP GDYVYIFHSF RMEECAPGGC LMELCIQLSI IMLGKQLIQN NLFEIGIPKM
     KKFIRYLRLK QQSPAHHEES VKRRQRYEVD YNLEPFAGLT PEYMEMIIQF GFVTLFVASF
     PLAPLFALLN NIIEIRLDAK KFVTELRRPV AVRAKDIGIW YNILRGIGKL AVIINAFVIS
     FTSDFIPRLV YLYMYSKDGT MHGFVNHTLS SFNVSDFQNG TAPNDPLDLG YEVRICRYKD
     YREPPWSENK YDISKDFWAV LAARLAFVIV FQNLVMFMSD FVDWVIPDIP KDISQQIHKE
     KVLMVELFMR EEQDKQQLLD TWMEKERQKD EAPCNHHNPK ACPDSLGSPA PSHAYHGGVL
//