ID A0A2K5F2B8_AOTNA Unreviewed; 3802 AA.
AC A0A2K5F2B8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Lysosomal trafficking regulator {ECO:0000313|Ensembl:ENSANAP00000039580.1};
GN Name=LYST {ECO:0000313|Ensembl:ENSANAP00000039580.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000039580.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000039580.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 37293.ENSANAP00000039580; -.
DR Ensembl; ENSANAT00000057681.1; ENSANAP00000039580.1; ENSANAG00000037136.1.
DR GeneTree; ENSGT00940000156359; -.
DR OMA; MGAPPEF; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0032510; P:endosome to lysosome transport via multivesicular body sorting pathway; IEA:Ensembl.
DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0043473; P:pigmentation; IEA:Ensembl.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 3010..3116
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 3121..3423
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3613..3647
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 108..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1182..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1221..1257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3802 AA; 429774 MW; B91026F4B6E1E2E6 CRC64;
MSTNSNSLAR EFLTDVNRLC NAVVQRVEIR EEEEEETHMA TLGQYLVHGR GFLLLTKLNS
IIDQALTCRE ELLTLLLSLL PLVWKIPVQE EKATDFNLPL SADTILTKEK NSSSQRSTQE
KLHLEGSALS SQVSTKVNVF RKNRRQRKIT HRYSIRDARK TQLSTSDSEA NSDEKGIAMN
KHRRPHLLQH FVTSFPKEDH PKAKLDHLVT KEEHTPPDTM ASENSRESIP RQESNTDILS
EPAALSVISN MNNSPFDLCH VLLSLLEKVC KFDITLNHNS PLAASVVPTL TEFLAGFGDC
CSLSDNLESR VVSAGWTEEP VALIQRMLFR TVLHLMSVDV STAEMIPENL RKNLTELLRA
ALKIRTCLEK QPDPFAPRQK KTLQEVQEDF VFSKYRHRAL LLPELLEGVL QILICCLQSA
ASNPFYFSQA MELVQEFIQH HGFNLFETAV LQMEWLILRD GVPPEASEHL KALINSVMKI
MSTVKKVKSE QLHHSMCTRK RHRRCEYSHF MHHHRDLSGL LVSAFKNQVS KNPFEETADG
DVYYPERCCC IAVCAHQCLR LLQQASLSST CVQILSGVHN VGICCCMDPK SVIIPLLHAF
KLPALKSFQQ HILNILNKLI LDQLGGAEVS QKIKKAACNI CTVDSDQLAQ LEETLQGNLC
DAEPSSSLSS PSYRFQGILP SSGSEDLLWK WDALKAYQNF VFEEDRLRSI QIANHICSLI
QKGNIVVQWK LYNYIFNPVL QRGVELAHHC QHLSIASAQT HVCSHHNQCL PQDVLQIYVK
TLPILLKSRV IRDLFLSCNG VNQIIELNYL NGIRSHSLKA FETLIISLGE QQKGASVPSI
DGIDIEQKEL SSVNVGTSFH HQQAYSDSPQ SLSKFYAGLK EAYPKRRKTV NQDVHINTIN
LFLCVAFLCI SKEAESDRES ANDSEDTSGY DSTASEPLSH MLPCLSLESL VLPSPEHMHQ
AADIWSMCRW IYMLSSVFQK QFYRLGGFRV CHKLIFMIIQ KLFGSHKEEQ GKKEEDTNVN
ENQDLNRISG PEITMKEDLL SLTIKSDPIP SELGTLKKSA DSLGKLELQH ISSINVEQIS
STEAAPKEAK IFTNQESETS LQSIRLLEAL LAICLHSAKT SQQKMELELP NQNLSVENIL
FEMRDHLSQS KVIETQLAKP LFDALLRVAL GNYSADFEHN DAMTEKSHQS AEELSSQPGD
FSEEAEDSQC SSFKLLVEEE GYEADSESNP EDGETQDDGV DLKSETEGFS TSSSPNDLLE
NLTQGEIIYP EICLLELNLL SASKAKLDVL AHVFESFLKI IRQKEKNVFL LMQQGTVKNL
LGGFLSILTQ GHSDFQACQR ALVDLLVSLM SSRTCSEELT LLLRIFLEKS PCTKIILLGI
LKIIESDTTM SPSQYLTFPL LHTSNLSNGV SSQKYPGILN SKAMGLLRRA RVSRSKKEAD
RESFPHRLLS SWHIAPVHLP LLGQNCWPHL SEGFSVSLWF NVECIHEAES TTEKGKKIKK
RNKSLILRDS SFDGTESDRP EGAEYINPGE RLIEEGCIHI ISLGSKALMI QVWADPHSAT
FIFRVCMDSN DDMKAVLLAQ VESQENIFLP SKWQHLVLTY LQQPQGKKKI HGKISIWVSG
QRKPDVTLDF MLPRKTSLSS DSNKTFCMIG HCLSSQEEFL QLAGKWDLGN LLLFNGAKVG
SQEAFYLYAC GPNHTSIMPC KYGKPVNDYS KYINKEILQC EQIRELFMTK KDVDIGLLIE
SLSVVYTTYC PAQYTIYEPV IRLKGQMKTQ LSQRPFSSKE VQSILLEPHH LKNLQPTEYK
TIQGILHEIG GTGIFVFLFA RVVELSSCEE TQALALQIIL SLIKYNQQRV HELENCNGLS
MIHQVLIKQK CIVGFYILKT LLEGCCGEDV IYMNENGEFK LDMESNAIIQ DVKLLEELLL
DWKIWNKAEQ GVWETLLAAL EVLIRADHHQ QMFNIKQLLK AQVVHHFLLT CQVLQEHKEG
QLTSMPREVC RSFVKIIAEV LGSPPDLELL TIIFNFLLAV HPPTNTYVCH NPTNFYFSLH
IDDKIFQEKV QSIMYLRHSS SGGRSLTSPG FMVISPSGFT ASPYEGENSS NIIPQQMAAH
MLRSRSLPAF PTSSLLRQSQ KLTGSLGCSI DRLQNIADTY VATQSEKQNS FESSNTLKKG
KEDAFISSCE SAKTVCEMEA VLSAQVSVSD VRKGMLGFPV VKVDHKELGA EPRSEDDSPG
DESCPRRPDY LKGLASFQRS HSTIASLGLA FPSQNGSAAI GRWPSLVDGN TDDWENFAYS
LGYEPNYNRT ASAHSVTEDC LVPICCGLYE LLSGVLLILP DIMLEDVMDK LIQADTLLVL
VNHPSPAIQQ GVIKLLDAYF ARASKEQKDK FLKNRGFSLL ANQLYLHRGT QELLECFIEM
FFGRRVGFDE EFDLEDVKNL GLFQKWSVIP ILGLIETSLY DNILLHNALL LLIQILNSCS
KVADMLLDNG LLYVLCNTVA ALNGLEKNIP VSEYKLLACD IQQLFIAVTI HACSSSGSQY
FRVIEDLIVM LGYLQNSKNK RTQNMAIALQ LRVLQAAMEF IRTTANHDSE NLTDSLQSPS
APHHAIVQKR KSIAGPRKFP LAQTESLLMK MRSVANDELH VMMQRRMSQE NPSQATETEL
AQRLQRLTIL AVNRIIYQEF NSDIIDILRT PENVTQSKTS VFQTEISEEY IHHEQSSVFN
PFQKEIFTYL VEGFKVSIGS SKTSGSKQQW TKILWSCKET FRMQLGRLLV HILSPAHAAR
ERKQIFEIVH EPNHQEILRD CLSPSLQHGA KLVLYLSELI HNHQDELTEE ELDTAELLMN
ALKLCGHKCI PPSASTKADL IKIIKEEQKK YETEEGANKA AWQKTVNNNQ QSLFQRLDSK
SKDISKIAAD ITQAVSLSQG IERKKVIQHI RGMYKVDLSA SRHWQELIQQ LTHDRAVWYD
PIYYPTSWQL DPTEGPNRER RRLQRCYLTI PNKYLLRDRQ KSEDVVKPPL SYLFEDKTHS
SFSSTVKDKA ASESIRVNRR CISVAPSRET AGELLLGKCG MYFVEDNASD TVESSNLQGE
LEPASFSWTY EEIKEVHKRW WQLRDNAVEI FLTNGRTLLL AFDNTKVRDE VYHNILTNNL
PNLLEYGNIT ALTNLWYTGQ ITNFEYLTHL NKHAGRSFND LMQYPVFPFI LADYVSETLD
LNDPLIYRNL SKPIAVQYKE KEDRYVDTYK YLEEEYRKGA REDDPMPPVQ PYHYGSHYSN
SGTVLHFLVR MPPFTKMFLA YQDQSFDIPD RTFHSTNTTW RLSSFESMTD VKELIPEFFY
LPEFLVNREG FDFGVRQNGE RVNHVNLPPW ARNDPRLFIL IHRQALESDY VSQNICQWID
LVFGYKQKGK ASVQAINVFH PATYFGMDVS AVEDPVQRRA LETMIKTYGQ TPRQLFHTAH
VSRPGAKLNI EGELPAAVGL LVQFAFRETR EQVKEITYPS PLSWIKGLKW GEYVGSPSAP
VPVVCFSQPH GERFGSLQAL PTRAICGLSR NFCLLMTYSK EQGVRSMNST DIQWSAILSW
GYADNILRLK SKQSEPPVNF IQSSQQYQVT SCAWVPDSCQ LFTGSKCGVI TAYTNRFTSS
TPSEIEMETQ IHLYGHTEEI TSLFVCKPYS ILISVSRDGT CIIWDLNRLC YVQSLAGHKS
PVTAVSASET SGDIATVCDS AGGGSDLRLW TVNGDLVGHV HCREIICSVA FSNQPEGISI
NVIAGGLENG IVRLWSTWDL KPVREITFPK SNKPIISLTF SCDGHHLYTA NSDGTVIAWC
RKDQQRLKQP MFYSFLSSYA AG
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