ID   A0A2K5F2G9_AOTNA        Unreviewed;       546 AA.
AC   A0A2K5F2G9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=T-box transcription factor 4 {ECO:0000313|Ensembl:ENSANAP00000039647.1};
GN   Name=TBX4 {ECO:0000313|Ensembl:ENSANAP00000039647.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000039647.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000039647.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00201}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR   RefSeq; XP_012300825.1; XM_012445402.1.
DR   AlphaFoldDB; A0A2K5F2G9; -.
DR   STRING; 37293.ENSANAP00000039647; -.
DR   Ensembl; ENSANAT00000057748.1; ENSANAP00000039647.1; ENSANAG00000037206.1.
DR   GeneID; 105712417; -.
DR   CTD; 9496; -.
DR   GeneTree; ENSGT00940000158882; -.
DR   OMA; QYHSGVG; -.
DR   OrthoDB; 5323209at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
DR   GO; GO:1990401; P:embryonic lung development; IEA:Ensembl.
DR   GO; GO:0030324; P:lung development; IEA:Ensembl.
DR   GO; GO:0002009; P:morphogenesis of an epithelium; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
DR   CDD; cd20189; T-box_TBX4_5-like; 1.
DR   Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR   PANTHER; PTHR11267:SF29; T-BOX TRANSCRIPTION FACTOR TBX4; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00201};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          71..251
FT                   /note="T-box"
FT                   /evidence="ECO:0000259|PROSITE:PS50252"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          480..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   546 AA;  60228 MW;  1EFF6C5197D58FD3 CRC64;
     MLQDKGLSES EEAFRAPGPA LGEASAANVP EPALAAPGLS GAALGSPPGP GADVVAAATA
     EQTIENIKVG LHEKELWKKF HEAGTEMIIT KAGRRMFPSY KVKVTGMNPK TKYILLIDIV
     PADDHRYKFC DNKWMVAGKA EPAMPGRLYV HPDSPATGAH WMRQLVSFQK LKLTNNHLDP
     FGHIILNSMH KYQPRLHIVK ADENNAFGSK NTAFCTHVFP ETSFISVTSY QNHKITQLKI
     ENNPFAKGFR GSDDSDLRVA RLQSKEYPVI SKSIMRQRLI SPQLSGTPDV GPLLGTHQAL
     QHYQHENGAH SQLAEPQDLP LSTFPAQRDS SLFYHCLKRR ADGARHLDLP CKRSYLEAPS
     SVGEDHYFRS PPPYDQQMLS PSYCSEVTPR EACMYSGSGP EIAGVSGVDD LPPPPLSCNM
     WTSVSPYTSY SVQAMETVPY QPFPTHFTAT TMMPRLPTLS AQSSQPPGNT HFSVYNQLSQ
     SQVRERGPSA SFPRERGLPP GCERKPPSPH LNAANEFLYS QTFSLSRESS LQYHSGMGTV
     ENWTDG
//