ID A0A2K5F2U3_AOTNA Unreviewed; 1294 AA.
AC A0A2K5F2U3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Crumbs cell polarity complex component 1 {ECO:0000313|Ensembl:ENSANAP00000039797.1};
GN Name=CRB1 {ECO:0000313|Ensembl:ENSANAP00000039797.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000039797.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000039797.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSANAT00000057899.1; ENSANAP00000039797.1; ENSANAG00000037265.1.
DR GeneTree; ENSGT00940000155152; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 11.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF1; PROTEIN CRUMBS HOMOLOG 1; 1.
DR Pfam; PF00008; EGF; 11.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF02210; Laminin_G_2; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01983; NOTCH.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00179; EGF_CA; 13.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 9.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 7.
DR PROSITE; PS00022; EGF_1; 12.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 14.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1294
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014348448"
FT TRANSMEM 1232..1256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..108
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 110..146
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 148..184
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 186..225
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 227..283
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 285..327
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 329..369
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 373..558
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 560..596
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 602..773
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 775..811
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 838..1025
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1027..1063
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1065..1100
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1102..1138
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1143..1183
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1185..1221
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 79..96
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 98..107
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 136..145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 174..183
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 273..282
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 359..368
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 586..595
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 801..810
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1053..1062
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1069..1079
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1090..1099
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1128..1137
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1173..1182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1211..1220
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1294 AA; 141533 MW; 013DA2D4830E127B CRC64;
MALKNIKYLL IFYLSFSLLI YIKNSFCNKN NTSCLSNSCQ NNSTCKGFSK DDGCSCSETA
NNLDKDCDNM KDPCFSNPCR GSATCVTIPG ERSFLCKCPP GYSGTSCETT IGSCGMNSCQ
HGGICHQDPI YPVCICPAGY AGRFCEIDHD ECASSPCQNG AVCQDGINGY SCFCVPGYQG
RHCNLEVDEC ASDPCKNEAT CLNEIGRYTC ICPHDYSGYT GVQCEIDINE CSSNPCQSDG
ECVELSSEKK YGHIVGLPSS FSSHEASGYV CICQPGFTGI YCEEDVNECS SNPCQNGGTC
ENLPGNYTCH CPFDNLSRTF YGGRDCSDIL LGCTHQQCLN NGICIPHFQD GQHGFSCLCP
SGYTGSLCEI ATTLSFEGGG FLWVTSDSVT TEDSVCNVAL RFQTVQPMAL LFFRGNRDVF
VKLELLSGYM HLSIQVNNQP KVLLYISHNT SDGEWHFVEV IFAEAVTLTL IDDSCKEKCI
TKAASPLESD QSICTFQNSF LGGLPVGSTS SDAALLNFYN IPSTPSFVGC LQDIKIDWNH
ITLENISSGS SLNVKPGCVR KDWCESQPCQ SRGHCINLWL SYQCDCHRPY KGSNCLREYV
AGKFGQDDST GYAVFTLDES YGDSVSLSMF VRTLHPSGLL LALENSTYQY IRVWLEHGRL
VMLTPSSPKL VVKFVLNDGN VHLITLKIKP NKIELYKSSQ NLGFISASTW KIQKGDVIYI
GGLPDRQETE LNGGFFKGCV QDVRLNNQNL EFFSNSTNEA SLNAVLVNVT QGCPGDNICE
SNPCHNGGVC HSLWDDFSCS CPANTSGKAC EEAQWCGLSP CPPRAQCQLV PQGFECIANA
VFNGQSSQIL FRSNGNITRE LTNTTFGFRT RDANVIILHA EKEPEFLNIS IQDSRLFFQL
QSGNSFYTLS LTSLQSVNDG MWHQVTLSMT DPLAQTSRWQ MEVDNQPPFV TSTIATGSLN
FLKDNTDIYV GGRAIDNIKG LQGCLSTIEI GGIYLSYFEN VRGFTNKPQE EQFLKISTNS
VVTGCLQLNA CNSNPCLHGG NCEDIYSSYH CSCPLGWSGK HCELNIDECF SNPCIHGNCS
DRVAAYHCRC EPGYTGVNCE VDIDNCQSHQ CANGATCISD TSGYSCLCLG NFTGKFCRQS
RLPSTVCGNE RTNLTCYNGG NCTEFQAELK CMCWPGFTGE RCEKDIDECA SDPCVNGGLC
QDLLNKFQCL CDVAFAGERC EVDLADGLIS DVFTALGSVT LALLLILLLA VVASVVTSNK
RATQGTYSPS RQEKEGSRVE MWNLMPPPAM ERLI
//
