ID A0A2K5F3Y8_AOTNA Unreviewed; 1001 AA.
AC A0A2K5F3Y8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Protein HIRA {ECO:0000256|ARBA:ARBA00021597, ECO:0000256|RuleBase:RU364014};
GN Name=HIRA {ECO:0000313|Ensembl:ENSANAP00000040187.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000040187.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000040187.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR AlphaFoldDB; A0A2K5F3Y8; -.
DR Ensembl; ENSANAT00000058294.1; ENSANAP00000040187.1; ENSANAG00000037418.1.
DR GeneTree; ENSGT00550000074919; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 58..90
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 119..151
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 162..193
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 748..946
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 389..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1001 AA; 110060 MW; A921F640057AE173 CRC64;
MDHLRPPIFS VDIHPDGTKF ATGGQGQDSG KVVIWNMSPV LQEDDEKDEN IPKMLCQMDN
HLACVNCVRW SNSGMYLASG GDDKLIMVWK RATYIGPSTV FGSSGKLANV EQWRCVSILR
NHSGDVMDVA WSPHDAWLAS CSVDNTVVIW NAVKFPEILA TLRGHSGLVK GLTWDPVGKY
IASQADDRSL KVWRTLDWQL ETSITKPFDE CGGTTHVLRL SWSPDGHYLV SAHAMNNSGP
TAQIIEREGW KTNMDFVGHR KAVTVVKFNP KIFKKKQKNG SSAKPSCPYC CCAVGSKDRS
LSVWVTFVAG RERDLLWVMT LNGLGILVCS MDGSVAFLDF SQDELGDPLS EEEKSRIHQS
TYGKSLAIMT EAQLSTAVIE NPEMLKYQRR QQQQQQLDQK SASTRETGSA TSVAGVVNGE
SLEDIRKNLL KKQVETRTAD GRRRITPLCI AQLDTGDFST AFFNSIPLSG SLAGTMLSSH
SGPQLLPLDS STPNSFGASK PCTEPVVAAS ARPAGDSVNK DSMNATSTPA ALSPSVLTTP
SKIEPMKAFD SRFTERSKAT PGAPALTSVT PTAMERLKEQ NFVKELRPRD LLESSSDSDE
KVPLTKPSSL SKRKLELEVE TVEKKKKGRP RKDSRLMPVS LSVQSPATLT AEKEAMCLSA
PALALKLPIP GPQRAFTLQV SSDPSMYIEV ENEVTVVGGV KLSRLKCNRE GKEWETVLTS
RILTAAGSCD VVCVACEKRM LSVFSTCGRR LLSPILLPSP ISTLHCTGSY VMALTAAATL
SVWDVHRQVV VVKEESLHSI LAGSDMTVSQ ILLTQHGIPV MNLSDGKAYC FNPSLSTWNL
VSDKQDSLAQ CADFRSSLPS QDAMLCSGPL AIIQGRTSNS GRQAARLFSV PHVVQQETTL
AYLENQVAAA LTLQSSHEYR HWLLLYARYL VNEGFEYRLR EICKDLLGPV HYSTGSQWES
TVVGLRKREL LKELLPVIGQ NLRFQRLFTE CQEQLDILRD K
//
