ID A0A2K5F4T5_AOTNA Unreviewed; 1128 AA.
AC A0A2K5F4T5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Potassium calcium-activated channel subfamily U member 1 {ECO:0000313|Ensembl:ENSANAP00000040414.1};
GN Name=KCNU1 {ECO:0000313|Ensembl:ENSANAP00000040414.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000040414.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000040414.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A2K5F4T5; -.
DR STRING; 37293.ENSANAP00000040414; -.
DR Ensembl; ENSANAT00000058523.1; ENSANAP00000040414.1; ENSANAG00000037568.1.
DR GeneTree; ENSGT00940000161817; -.
DR OMA; AWNQSRT; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:Ensembl.
DR GO; GO:0022414; P:reproductive process; IEA:Ensembl.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR048735; Slowpoke-like_C.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF23; POTASSIUM CHANNEL SUBFAMILY U MEMBER 1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF21014; Slowpoke_C; 1.
DR PRINTS; PR01449; BKCHANNELA.
DR PRINTS; PR00169; KCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 94..307
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 457..544
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT DOMAIN 902..1016
FT /note="Ca2+-activated K+ channel Slowpoke-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21014"
FT REGION 817..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1042..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1080..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1108..1128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1128 AA; 127190 MW; 7D4D06A1CD2A8A49 CRC64;
MFQTSFRLSS RLTFILSSFI TFFGGLIILL IFRWIWRVVK KWRIIKGTGI ILELFTSGSI
GKDPVRSLRF QGQFHYHIQM LLSAQTFVGQ VLMILVFVLS IGSLIIYLIN STDPVRSCSS
YEDKTIPIDL AFNAFFSFYF GLRFMAADDK IKFWLEVNSI VDIFTIPPTF ISYYLKSNWL
GLRFLRALRL LELPRILQIL RATKTSDSVK FSKLLSVTLS TWFTAAGFIH LVENSGDPWL
KGRNSQTISY FESLYLVVIT TSTVGFGDVV PKTSLGRTFM MFFTLGSLIL FANFIPEMVE
LFANKRKCTS SYEALKGKKF IVVCGNITVD SVTAFLRNFL RHKSGEINTE IVFLGETPPS
LELETIFKCY LAYTTFISGS AMKWEDLRRV AVESAEACLI IANPLCSDSD AEDISNIMRV
LSIKNHFPTS RVIIQILQSH NKVYLPKIPS WNWSTGDNII CFAELKLGFI AQGCLVPGLC
TLLTSLFVEQ NKKVSPKQTW QKYFLNGMKN KILTQRLSDD FTGMSFPEVA RLCFLKMHLL
LIAIEYKSLF NDGFCGLILN PPAQVKIHRN TLGFFIAETP KEVKRALFYC EKCHKDVFIP
ERITNCGCKS RNRQRIPVPS VKLVEHCIMG FSSRIAAQDS PPREGANTTN IPSVTARTLL
QEAEQDSDQL DSSGMFHWCK TTPLDNVILK RTDKLKHEFQ NHIVACVFGD AHSALVGLRN
FVMPLRASNY TRQELKDIVF IGSLDYLQRE WQFLWNFPQI HILPGSALYP EDLHAANIEQ
CSMCVVLSPP SKSSSSQMLV DTETIMATLI IRSLQTDSSS DPSLNTPGYT SGPNGKSKHQ
RVPILTELKN PSNIHFIEQP GGLEGSLQER NLHLSTAFST GTVFSGSFLD SLLATAFYNY
RVLELLQMLV TGGISSQLEQ HLDKDKVYDL SDSCTTLLSG RKRCKLGLLS LHQTILSDVQ
PRDNFGQLFC GSLDLFGILC VGLYRVIDEE DLNPENKRGV SNGFTLLPSD LVFCAIPFST
ACYKRNEESL LQKSNEIVNN APQTTETYSD PNFPPTIDPG DETLYSPVYP YESRSKSPFA
KQTSWEQSRT HSVTSSPILL GDSANENGRQ TSDKEIYDED SFAYSEPH
//
