ID   A0A2K5F509_AOTNA        Unreviewed;      1626 AA.
AC   A0A2K5F509;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=DENN domain containing 4A {ECO:0000313|Ensembl:ENSANAP00000040489.1};
GN   Name=DENND4A {ECO:0000313|Ensembl:ENSANAP00000040489.1};
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000040489.1, ECO:0000313|Proteomes:UP000233020};
RN   [1] {ECO:0000313|Ensembl:ENSANAP00000040489.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSANAT00000058598.1; ENSANAP00000040489.1; ENSANAG00000037563.1.
DR   GeneTree; ENSGT00940000155836; -.
DR   OMA; FNDICHK; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR002885; Pentatricopeptide_rpt.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   NCBIfam; TIGR00756; PPR; 1.
DR   PANTHER; PTHR12296:SF16; C-MYC PROMOTER-BINDING PROTEIN; 1.
DR   PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF03455; dDENN; 1.
DR   Pfam; PF02141; DENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   PROSITE; PS50211; DENN; 1.
DR   PROSITE; PS51375; PPR; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233020}.
FT   DOMAIN          1..405
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   REPEAT          573..607
FT                   /note="PPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT   REGION          483..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          669..716
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          841..875
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          941..965
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1010..1048
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1111..1136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        484..502
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        675..702
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        849..867
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1028..1042
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1111..1133
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1626 AA;  182677 MW;  F452795F44AF7FAE CRC64;
     MGATIECWPS NSKYPLPVFS TFVLTGASAE KIYGAAIQFY EPYSEENLTE KQRLLLGLTS
     ADGKSDSSKT VHTSKCICLL SHWPFFDAFR KFLTFLYRYS ISGPHVLPIE KHISHFMHKV
     PFPSPQRPRI LVQLSPHDNL ILSQPVSSPL PLSGGKFSTL LQNLGPENAV TLLVFAVTEH
     KILIHSLRPS VLTSVTEALV SMIFPFHWPC PYVPLCPLAL ADVLSAPCPF IVGIDSRYFD
     LYDPPPDVSC VDVDTNTISQ TGDKKNVAWK ILPKKPCKNL MNTLNNLHQQ LAKLQQRPRD
     DGLMDLAMND YDFNSGKRLH MIDLEIQEAF LFFMASILKG YRSYLRPITQ APSETATDAA
     SLFALQAFLR SRDRSHQKFY NMMTKTQMFI RFIEECSFVS DKDASLAFFD DCVDKVDMDK
     SGEVRLIELD ESFKSEHTVF VTPPEIPHLP NGEEPPLQYS YNGFPVLRNN LFERPEGFLQ
     AKKNKLPSKS SSPNSPSPMF RRTKQEIKSA HKIAKRYSSI PQMWSRCLLR HCYGLWFICL
     PAYVKVCHSK VRALKTAYDV LKKMQSKKMD PPDEVCYRIL MQLCGQYDQP VLAVRVLFEM
     QKAGIDPNAI TYGYYNKAVL ESTWPSRSRS GYFLWTKVRN VVLGVTQFKR ALKKHAHLSQ
     TTLSGGQSDL GYNSLSKDEV RRGDTSTEDI QEEKDKKGSD CSSLSESESA KGSADCLPKL
     GYQSSSSIVR LTGTSNNSAD KISGESMEST PELLLISSLE DTNDTGNIQS RCFRKRHKSD
     NETNLQQQVV WGNRNRNLSG GVLMGFMLNR INQEATPGDI VEKLGADAKI LSNVISKRTR
     PNTLDIGKPS LRSKRDSLEK ESSDDDTPFD GSNYLADKMD SPVIFDLEDL DSETDGSKAG
     CIATQNPKRI QRMNSNFSIK PFEKTDVATG FDPLSLLVAE TEQQKEEEEE DEDDSKSIST
     PSARRDLAEE IVMYMNNMSS PLTSRTPSID LQRACDDKLN KKSPTLVKAC RRSSLPPNSP
     KPVRLTKSKS YTKSEEKPRD RLWSSPAFSP TCPFREESRD TLIHSSPSFN LDTLLVPKLD
     VLRNSMFTAG KGVAEKASKW YSRFTMYTTS SKDQSSDRTS LSSVGAQDSE STSLTDEDVC
     HELEGAAASQ ETSATSGTKG IDLSQISLES SASLEGSLSK FALPGKSEVT SSFNMSNTNI
     FQNYAMEVLI SSCSRCRTCD CLVHDEEIMA GWTADDSNLN TTCPFCGNLF LPFLNIEIRD
     LRRPGRYFLK SSPSTENMHF PSSFSSQTRQ SCISTSASGL DTSAVSVQGN FDLNSKSKLQ
     ENFCARSIQI PANRSKTATS KCPIFPMTRS ISTCGPLDKE ETGRQKLIPT GSLPATLQGA
     TDSLGLEWHI PSPDPVTVPY LSPLVVWKEL ESLLENEGDH AITVADFVDH HPIVFWNLVW
     YFRRLDLPSN LPGLILSSEH CNKYSKIPRH CMSEDSKYVL IQMLWDNMKL HQDPGQPLYI
     LWNAHTQKYP MVHLLQKSDN SFNQELLKSM VKSIKMNDVY GPMSQILETL NKCPHFKRQR
     SLYREILFLS LVALGRENID IDAFDKEYKM AYDRLTPSQV KSTHNCDRPP STGVMECRKT
     FGEPYL
//