ID A0A2K5F8V8_AOTNA Unreviewed; 1452 AA.
AC A0A2K5F8V8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 {ECO:0000313|Ensembl:ENSANAP00000041887.1};
GN Name=ARAP1 {ECO:0000313|Ensembl:ENSANAP00000041887.1};
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293 {ECO:0000313|Ensembl:ENSANAP00000041887.1, ECO:0000313|Proteomes:UP000233020};
RN [1] {ECO:0000313|Ensembl:ENSANAP00000041887.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 37293.ENSANAP00000041887; -.
DR Ensembl; ENSANAT00000060003.1; ENSANAP00000041887.1; ENSANAG00000038203.1.
DR GeneTree; ENSGT00940000157424; -.
DR Proteomes; UP000233020; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR GO; GO:0051497; P:negative regulation of stress fiber assembly; IEA:Ensembl.
DR GO; GO:0051491; P:positive regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08837; ArfGap_ARAP; 1.
DR CDD; cd13253; PH1_ARAP; 1.
DR CDD; cd13254; PH2_ARAP; 1.
DR CDD; cd13256; PH3_ARAP; 1.
DR CDD; cd13257; PH4_ARAP; 1.
DR CDD; cd13259; PH5_ARAP; 1.
DR CDD; cd17226; RA_ARAP1; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR CDD; cd09490; SAM_Arap1_2_3; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR45899:SF3; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 3.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00536; SAM_1; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 4.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233020};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 10..64
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 328..420
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 441..530
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 536..652
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 744..851
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 955..1140
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1173..1263
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1276..1398
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 67..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..106
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..221
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..289
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..322
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1452 AA; 162279 MW; 6C37C1DF54DFED15 CRC64;
MAEAGDAALS VAEWLRALHL EQYTGLFEQH GLVWATECQG LSDARLMDMG MLLPGHRRRV
LAGLLRAHNP PAPAPRPTPR PVPMKRHIFR SPPAPATPPE PPPAAATEDE GLPAAPPIPP
RRSCLPPTCF AAPSTAVPDP VLPPLPAKQH LAELSVPPVP PRTVPPRLLM SLPSKEEESL
LPSLSSPPQP EPEEPLSPLP QAPPHSPSPS PCPPEIPPKP VRLFPEFDDS DYDEVPEEGP
GAPARVMTKK EEPPPSQIPR AVRVASLLSE GEELSGDDQG DEDEDDHDYE GVPNGGWHTS
SLSLPLPRPV TAPHPMDGPP GGATPITPVI KAGWLDKNPP QGSYIYQKRW VRLDADHLRY
FDSNKDAYSK RFISVACISR VAAIGDQKFE VITNNRTFAF RAESDVERKE WMQALQQAMA
EQRARARLSS AYLLGVPGSE QPDRAGSLEL RGFKNKLYVA VVGDKVQLYK NREEYQLGIG
ITFIDMSVGN VKEVDRRSFD LTTPYRIFSF SADSELEKEQ WLEAMQGAIA EALSTSEVAE
RIWAAAPNRF CADCGAAQPD WASINLCVVI CKRCAGEHRG LGAGVSKVRS LKMDRKVWTE
TLIQLFLQLG NGAGNRFWAA NVPPSEALQP SSSPSTRRRH LEAKYCEGKY RRYHPLFGNQ
EELDKALCAA VTTTDLAETQ ALLGCGAGIS CFSGDPEAPT PLALAEQAGQ TLQMEFLRNN
RTTEVPRLDS MKPLEKHYSV VLPTVSHSGF LYKTASAGKL LQDRRAREEF SRRWCVLSDG
VLSYYENERA VTPNGEIRAS EIVCLAVPPP DTHGFEHTFE VYTEGERLYL FGLESAEQAH
EWVKCIAKAF VPPLAEDLLA RDFERLGRLP YKAGLSLQRA QEGWFSLSGS ELRAVFPEGP
CEEPLQLRKL QELSIQGDSE NQVLVLVERR RTLYIQGERR LDFMGWLGAI QKAAASLGDT
LSEQQLGDSD IPVIVYRCVD YITQCGLTSE GIYRKCGQTS KTQRLLESLR QDARSVHLKE
GEQHVDDVSS ALKRFLRDLP DGLFTRAQRL AWLEASEIED EEEKVSRYRE LLVRLPPVNR
ATVKALISHL YCVQCFSDTN QMNVHNLAIV FGPTLFQTDG QDYKAGHVVE DLISHYVVVF
SVDEEELRKQ REEITAIVKM RVAGTASGTQ HAGDFICTVY LEEKKAETEQ HIKVIPASMT
AEELTLEILD RRNVGIREKD YWTCFEVNER EEAERPLHFA EKVLPILHGL GTDSHLVVKK
HQAMEAMLLY LASRVGDTKH GMMKFREDRS LLGLGLPSGG FHDRYFILNS SCLRLYKEVR
SQRPWSGAPE TSHRPEKEWS VKSLKVYLGV KKKLRPPTCW GFTVVHETEK HEKQQWYLCC
DTQMELREWF ATFLFVQHDG LVWPSEPSRV SRAVPEVRLG SVSLIPLRGS ENEMRRSVAA
FTSDPLSLLR NV
//
