ID A0A2K5H6P4_COLAP Unreviewed; 1266 AA.
AC A0A2K5H6P4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Euchromatic histone lysine methyltransferase 2 {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000000023.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000000023.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011800142.1; XM_011944752.1.
DR AlphaFoldDB; A0A2K5H6P4; -.
DR STRING; 336983.ENSCANP00000000023; -.
DR Ensembl; ENSCANT00000000093.1; ENSCANP00000000023.1; ENSCANG00000000006.1.
DR GeneID; 105513763; -.
DR KEGG; cang:105513763; -.
DR CTD; 10919; -.
DR OrthoDB; 5481936at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd20905; EHMT_ZBD; 1.
DR CDD; cd10533; SET_EHMT2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR043550; EHMT1/EHMT2.
DR InterPro; IPR047762; EHMT_CRR.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR038034; SET_EHMT2.
DR PANTHER; PTHR46307; G9A, ISOFORM B; 1.
DR PANTHER; PTHR46307:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF21533; EHMT1-2_CRR; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT REPEAT 740..772
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 773..805
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 806..830
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 840..872
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 906..938
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1028..1091
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 1094..1211
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..384
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..421
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1266 AA; 138623 MW; 4B285E80CD97495D CRC64;
MRGLPRGRGL MRARGRGRAA PPGSRGRGRG GPHRGRGRPR SLLSLPRAQA SWTPQLSTGL
TSPPVPCLPS QGEAPAEMGA LLLEKETRGA TERVHGSLGD TPRSEETLPK ATPDSLEPAG
PSSPASVTVT VGDEGADTPV GATPLIGDES ENLEGDGDLH GGRILLGHAT KSFPSSPSKG
GSCPSRAKMS MTGAGKSPPS VQSLAMRLLS MPGAQGAAAA GPEPPPATTS PEGQPKVHRA
RKTMSKPGNG QPPVPEKRPP EVQHFRMSDD VHSLGKVTSD VVKRRKLTSG GGLSEELGSA
RRSEVTLAKG DPGSLEEWET VVGDDFSLYY DSYSVDERVD SDSKSEVEAL TEQLSEEEEE
EEEEEEEEEE EEEEEEEEED EESGNQSDRS GSSGRRKAKK KWRKDSPWVK PSRKRRKREP
PRAKEPRGVN GVGSSGPSEY MEVPLGSLEL PSEGTLSPNH AGVSNDTSSL ETERGFEELP
LCSCRMEAPK IDRISERAGH KCMATESVDG ELSGCNAAIL KRETMRPSSR VALMVLCETH
RARMVKHHCC PGCGYFCTAG TFLECHPDFR VAHRFHKACV SQLNGMVFCP HCGEDASEAQ
EVTIPRGDGV TPPAGAAAPA PPPLSQDAPG RADTSQPSAR MRGHGEPRRP PCDPLADTID
SSGPSLTLPN GGCLSAVGLP LGPGREALEK ALVIQESERR KKLRFHPRQL YLSVKQGELQ
KVILMLLDNL DPNFQSDQQS KRTPLHAAAQ KGSVEICHVL LQAGANINAV DKQQRTPLME
AVVNNHLEVA RYMVQRGGCV YSKEEDGSTC LHHAAKIGNL EMVSLLLSTG QVDVNAQDSG
GWTPIIWAAE HKHIEVIRML LTRGADVTLT DNEENICLHW ASFTGSAAIA EVLLNARCDL
HAVNYHGDTP LHIAARESYH DCVLLFLSRG ANPELRNKEG DTAWDLTPER SDVWFALQLN
RKLRLGVGNR AIRTEKIICR DVARGYENVP IPCVNGVDGE SCPEDYKYIS ENCETSTMNI
DRNITHLQHC TCVDDCSSSN CLCGQLSIRC WYDKDGRLLQ EFNKIEPPLI FECNQACSCW
RNCKNRVVQS GIKVRLQLYR TAKMGWGVRA LQTIPQGTFI CEYVGELISD AEADVREDDS
YLFDLDNKDG EVYCIDARYY GNISRFINHL CDPNIIPVRV FMLHQDLRFP RIAFFSSRDI
RTGEELGFDY GDRFWDIKSK YFTCQCGSEK CKHSAEAIAL EQSRLARLDP HPELLPELSS
LPPVNT
//
