ID A0A2K5H8G1_COLAP Unreviewed; 399 AA.
AC A0A2K5H8G1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50009};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000000624.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000000624.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5H8G1; -.
DR STRING; 336983.ENSCANP00000000624; -.
DR Ensembl; ENSCANT00000002589.1; ENSCANP00000000624.1; ENSCANG00000002313.1.
DR OMA; QATETSW; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF223; RAL-GDS-RELATED PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT DOMAIN 85..334
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 28..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 399 AA; 44048 MW; A25A5A4A601D4624 CRC64;
MLVLEPAPPL LVDLRPALES ESHATLDAPG YLHSAPAPAS TPAPGKGPPP GTLLELQSAP
ESSCPSPGTA KGQLSDELAD ITTFPPRLLA EQLTLMDAAL FKKVELYECM DSIWGQRHQK
GSEHVTPTVC ATIAYFNRLT NCVTTPCLGD HSMRAQDRAR VVEHWIKVAR ECLSLNNLSS
VHAMVSALHS NPIHRLHKMW AGVSSKSTKY LKELCKKDTA VKRDLLIKTG SFKVSTQERK
PQIAQMRLRR QKKGVVPFLR DFLTELHRLD SAILDDLDGN TNKRRKVSIL QEMQLLQVAA
MNYRLQSLEK FVTCFSKMEQ LSNKERLHCS VTISAHCNIC LLGSSPSSAS QVAGTTTIHH
HVRLFSCCCS GTSCPASWSP NPSRMLTRTT ALHHPSLRP
//
