ID A0A2K5H9Z1_COLAP Unreviewed; 176 AA.
AC A0A2K5H9Z1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Pituitary adenylate cyclase-activating polypeptide {ECO:0000256|ARBA:ARBA00014902};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000001156.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000001156.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with ADCYAP1R1 (via N-terminal extracellular
CC domain). {ECO:0000256|ARBA:ARBA00011487}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR RefSeq; XP_011813175.1; XM_011957785.1.
DR AlphaFoldDB; A0A2K5H9Z1; -.
DR STRING; 336983.ENSCANP00000001156; -.
DR Ensembl; ENSCANT00000004748.1; ENSCANP00000001156.1; ENSCANG00000004338.1.
DR GeneID; 105523055; -.
DR KEGG; cang:105523055; -.
DR CTD; 116; -.
DR OMA; LYGIIMH; -.
DR OrthoDB; 3925933at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0016521; F:pituitary adenylate cyclase activating polypeptide activity; IEA:UniProt.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR GO; GO:0032879; P:regulation of localization; IEA:UniProt.
DR Gene3D; 6.10.250.590; -; 1.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR InterPro; IPR046963; VIP/GHRH-like.
DR PANTHER; PTHR11213; GLUCAGON-FAMILY NEUROPEPTIDE; 1.
DR PANTHER; PTHR11213:SF1; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; 1.
DR Pfam; PF00123; Hormone_2; 2.
DR PRINTS; PR00275; GLUCAGON.
DR SMART; SM00070; GLUCA; 2.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..176
FT /note="Pituitary adenylate cyclase-activating polypeptide"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014404006"
FT DOMAIN 132..154
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
SQ SEQUENCE 176 AA; 19407 MW; 62EF6442626A6DFB CRC64;
MTMCSGARLA LLVYGIIMHS SVYCSPAAAG LRFPGIRPEE EAYDQDGNPL QDFYDLEPPG
AGSPASALRD ASALYYPSER RDVAHGILNK AYRKVLDQLS ARKYLQSLVA KGVGGNLGGG
VEEDAEPLSK RHSDGIFTDS YSRYRKQMAV KKYLAAVLGK RYKQRVKNKG RRIAYL
//