ID A0A2K5H9Z8_COLAP Unreviewed; 1652 AA.
AC A0A2K5H9Z8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=PDZ domain-containing protein {ECO:0000259|PROSITE:PS50106};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000001170.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000001170.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the LAP (LRR and PDZ) protein family.
CC {ECO:0000256|ARBA:ARBA00007772}.
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DR Ensembl; ENSCANT00000004762.1; ENSCANP00000001170.1; ENSCANG00000004194.1.
DR Proteomes; UP000233080; Unplaced.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF44; PROTEIN SCRIBBLE HOMOLOG; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00595; PDZ; 4.
DR SMART; SM00364; LRR_BAC; 10.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00228; PDZ; 4.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50106; PDZ; 4.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 730..817
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 864..952
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1012..1101
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1108..1196
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 418..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1235..1259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1293..1313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1328..1383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1411..1490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1518..1567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..694
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1438..1452
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1652 AA; 177325 MW; 767BA6AB5113F19F CRC64;
MLKCIPLWRC NRHVESVDKR HCSLQAVPEE IYRYSRSLEE LLLDANQLRE LPKPFFRLLN
LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES IKFCKALEIA DFSGNPLSRL
PDGFTQLRSL AHLALNDVSL QALPGDVGNL ANLVTLELRE NLLKSLPALL GMAQQEALPC
SHYSLCSFLQ PDTLGALPNL RELWLDRNQL SALPPELGNL RRLVCLDVSE NRLEELPAEL
GGLVLLTDLL LSQNLLRRLP DGIGQLKQLS ILKVDQNRLC EVTEAIGDCE NLSELILTEN
LLMALPRSLG KLTKLTNLNV DRNHLETLPP EIGGCAALSV LSLRDNRLAV LPPELAHTAE
LHVLDVAGNR LQSLPFALTH LNLKALWLAE NQAQPMLRFQ TEDDARTGEK VLTCYLLPQQ
PPSSLEDAGQ QGSLSESWSD APPSRVSVIQ FLEAPTGDED AEEAAAEKRG LQRRATPHPS
ELKVMKRSIE GRRSEACPCQ PDPGSPLPAE EEKRLSAESG LSEDSRPSAS TVSEAEPEGP
LAEAQGGSQQ EATTAGGEED AEEDYEEPAV HFAEDALLPG DDRESEEGQP EAPWTLPGGR
QRLIRKDTPH YKKHFKISKL PQPEAVVALL QGMQPDGEGP VAPGGWHNGP HTPWAPRAQK
EEEEEEEEGS PREEEEEEEE ENRAEEEEAS TEEEDKEGPV ASAPSVKGVS FDQANNLLIE
PARIEEEELA LTILRQTGGL GISIAGGKGS TPYKGDDEGI FISRVSEEGP AARAGVRVGD
KLLEVNGVAL QGAEHHEAVE ALRGAGTAVQ MRVWRERMVE PENAVTITPL RPEDDYSPRE
RRGGGLRLPL LPAESPGPLR QRHVACLARS ERGLGFSIAG GKGSTPYRAG DAGIFISRIA
EGGAAHRAGT LQVGDRVLSI NGVDVTEARH DHAVSLLTAA SPTIALLLER EAGGPLPPSP
PPHSSSLPTA AVAITSTTTT SITTATPGEP GLPSLAPSLL AATLEGPYPV EEIRLPRAGG
PLGLSIVGGS DHSSHPFGVQ EPGVFISKVL PRGLAARSGL RVGDRILAVN GQDMRDATHQ
EAVSALLRPC LELSLLVRRD PAPPGLRELC IQKAPGERLG ISIRGGARGH AGNPRDPTDE
GIFISKVSPT GAAGRDGRLR VGLRLLEVNQ QSLLGLTHGE AVQLLRGVGD TLTVLVCDGF
DAGSSAALEV SPGVIANPFA AGVSHRNSLE SISSIERELS PEGPGKEKEP PGQTLRWGPE
ATEATGRGLQ PLKLDYRALA AVPSAGGVQR VSAQCAVSPT PQPPSPPSPD ELPANVKQAY
RAFAAVPTSH PPEDALAQPP TPGPAASPEQ LSFRERQKYF ELEVRVPQAE GPPKRVSLVG
ADDLRKMQEE EARKLQQKRA QMLRDVAEAG AEARLALDGE ALGEEEQEDE EPPWAGPSPS
SRQSPASPPP LGGGAPVRTA KAERRHQERL RVQSPEPPAP ERALSPAERR ALEAEKRALW
RAARMKSLEQ DALRAQMVLS RSQEGRGTRG PLERLAEAPS PAPTPSPTPL EDLGPQTSTS
PGRLPLSGKK FDYRAFAALP SSRPVYDIQV PAALSSLPAC PCPPGPQEED GEVALVLLGR
PAPGAVGPED VALCSSRRPV RPGRRGLGPV PS
//
