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Database: UniProt
Entry: A0A2K5HBS3_COLAP
LinkDB: A0A2K5HBS3_COLAP
Original site: A0A2K5HBS3_COLAP 
ID   A0A2K5HBS3_COLAP        Unreviewed;       123 AA.
AC   A0A2K5HBS3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   05-DEC-2018, entry version 5.
DE   RecName: Full=Superoxide dismutase [Cu-Zn] {ECO:0000256|RuleBase:RU000393};
DE            EC=1.15.1.1 {ECO:0000256|RuleBase:RU000393};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000001799, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000001799, ECO:0000313|Proteomes:UP000233080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hughes D.S., Murali S., Raveendran M., Korchina V., Bandaranaike D.,
RA   Bellair M., Blankenburg K., Chao H., Dahdouli M., Dinh H.,
RA   Doddapaneni H., Gnanaolivu R., Gross S., Jayaseelan J., Jones J.,
RA   Khan Z., Kovar C., Kurapati P., Le B., Lee S., Mathew T.,
RA   Narasimhan A., Okwuonu G., Ongeri F., Osuji N., Qu C., Quiroz J.,
RA   Rajbhandari K., Reid J.G., Santibanez J., Skinner E., Wang Y., Xin Y.,
RA   Han Y., Muzny D.M., Richards S., Worley K.C., Rogers J., Gibbs R.A.;
RT   "Black and white colobus reference genome project.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCANP00000001799}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- FUNCTION: Destroys radicals which are normally produced within the
CC       cells and which are toxic to biological systems.
CC       {ECO:0000256|RuleBase:RU000393}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:18421; EC=1.15.1.1;
CC         Evidence={ECO:0000256|RuleBase:RU000393};
CC   -!- COFACTOR:
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC         Evidence={ECO:0000256|RuleBase:RU000393};
CC       Note=Binds 1 copper ion per subunit.
CC       {ECO:0000256|RuleBase:RU000393};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU000393};
CC       Note=Binds 1 zinc ion per subunit.
CC       {ECO:0000256|RuleBase:RU000393};
CC   -!- SIMILARITY: Belongs to the Cu-Zn superoxide dismutase family.
CC       {ECO:0000256|RuleBase:RU000393}.
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DR   Ensembl; ENSCANT00000007436; ENSCANP00000001799; ENSCANG00000006528.
DR   GeneTree; ENSGT00940000155551; -.
DR   Proteomes; UP000233080; Whole Genome Shotgun Assembly.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   CDD; cd00305; Cu-Zn_Superoxide_Dismutase; 1.
DR   Gene3D; 2.60.40.200; -; 1.
DR   InterPro; IPR036423; SOD-like_Cu/Zn_dom_sf.
DR   InterPro; IPR024134; SOD_Cu/Zn_/chaperone.
DR   InterPro; IPR018152; SOD_Cu/Zn_BS.
DR   InterPro; IPR001424; SOD_Cu_Zn_dom.
DR   PANTHER; PTHR10003; PTHR10003; 1.
DR   Pfam; PF00080; Sod_Cu; 1.
DR   PRINTS; PR00068; CUZNDISMTASE.
DR   SUPFAM; SSF49329; SSF49329; 1.
DR   PROSITE; PS00332; SOD_CU_ZN_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000233080};
KW   Copper {ECO:0000256|RuleBase:RU000393};
KW   Metal-binding {ECO:0000256|RuleBase:RU000393};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000393};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   Zinc {ECO:0000256|RuleBase:RU000393}.
FT   DOMAIN        4    119       Sod_Cu. {ECO:0000259|Pfam:PF00080}.
SQ   SEQUENCE   123 AA;  12835 MW;  1AA43D59A63F2696 CRC64;
     LQKESNGPVK VWRSITGLTE GLHGFHVHHA GPHFNPLSRQ HGGPKDEERH VGDLGNVTAG
     KDGVANVSFE DSVISLSGDH SIIGCTLVVH EKADDLGKGG NEESKKTGNA GSRLACGVIG
     IAQ
//
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