ID A0A2K5HEB8_COLAP Unreviewed; 230 AA.
AC A0A2K5HEB8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=MHC class II-associated invariant chain/CLIP MHC II-interacting domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000002692.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000002692.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011786972.1; XM_011931582.1.
DR AlphaFoldDB; A0A2K5HEB8; -.
DR Ensembl; ENSCANT00000010967.1; ENSCANP00000002692.1; ENSCANG00000009648.1.
DR GeneID; 105504233; -.
DR CTD; 972; -.
DR OrthoDB; 2972165at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035718; F:macrophage migration inhibitory factor binding; IEA:InterPro.
DR GO; GO:0042289; F:MHC class II protein binding; IEA:InterPro.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0070206; P:protein trimerization; IEA:InterPro.
DR Gene3D; 1.10.870.10; MHC class II-associated invariant chain, trimerisation domain; 1.
DR InterPro; IPR043530; CD74_antigen.
DR InterPro; IPR015386; MHC_II-assoc_invar/CLIP_MHC-bd.
DR InterPro; IPR022339; MHC_II-assoc_invar_chain.
DR InterPro; IPR011988; MHC_II-assoc_invariant_trimer.
DR InterPro; IPR036613; MHCII_invariant_trimer_sf.
DR PANTHER; PTHR14093; HLA CLASS II GAMMA CHAIN; 1.
DR PANTHER; PTHR14093:SF17; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN; 1.
DR Pfam; PF09307; MHC2-interact; 1.
DR Pfam; PF08831; MHCassoc_trimer; 1.
DR PIRSF; PIRSF001992; CD74_antigen; 1.
DR PRINTS; PR01990; CD74ANTIGEN.
DR SUPFAM; SSF48305; Class II MHC-associated invariant chain ectoplasmic trimerization domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..122
FT /note="MHC class II-associated invariant chain/CLIP MHC II-
FT interacting"
FT /evidence="ECO:0000259|Pfam:PF09307"
FT DOMAIN 134..202
FT /note="MHC class II-associated invariant chain
FT trimerisation"
FT /evidence="ECO:0000259|Pfam:PF08831"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 230 AA; 26219 MW; A997D40926B1304F CRC64;
MYRSSRRSCQ EDQKPVMDDQ RDLISNNEQL PMLGRRPGTP ESKCSRGALY TGFSILVTLL
LAGQATTAYF LYQQQGRLDK MTVTTQNLQL ENLRMKLPKP PKPVSKMRMA TPLLMQALPM
GAQGPMQNAT KYGNMTEDHV MHLLQNADPL KVYPPLKGSF PENLRHLKNT METLDWKVFE
SWMHHWLLFE MSRHSLEQKP TEAPPKELLE LEDPSSGLGV TKQDLGPVPM
//