ID   A0A2K5HEQ8_COLAP        Unreviewed;       781 AA.
AC   A0A2K5HEQ8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Actinin alpha 2 {ECO:0008006|Google:ProtNLM};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000002827.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000002827.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the alpha-actinin family.
CC       {ECO:0000256|ARBA:ARBA00010255}.
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DR   AlphaFoldDB; A0A2K5HEQ8; -.
DR   STRING; 336983.ENSCANP00000002827; -.
DR   Ensembl; ENSCANT00000011575.1; ENSCANP00000002827.1; ENSCANG00000010367.1.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd21214; CH_ACTN_rpt1; 1.
DR   CDD; cd21216; CH_ACTN_rpt2; 1.
DR   CDD; cd00176; SPEC; 1.
DR   Gene3D; 1.20.58.60; -; 4.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   InterPro; IPR001589; Actinin_actin-bd_CS.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014837; EF-hand_Ca_insen.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR11915:SF429; ALPHA-ACTININ-2; 1.
DR   PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR   Pfam; PF00307; CH; 2.
DR   Pfam; PF08726; EFhand_Ca_insen; 1.
DR   Pfam; PF00435; Spectrin; 4.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM01184; efhand_Ca_insen; 1.
DR   SMART; SM00150; SPEC; 2.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF47473; EF-hand; 2.
DR   SUPFAM; SSF46966; Spectrin repeat; 4.
DR   PROSITE; PS00020; ACTININ_2; 1.
DR   PROSITE; PS50021; CH; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1..100
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          109..215
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          676..711
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   COILED          230..257
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          395..478
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          629..663
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   781 AA;  90217 MW;  0E1CA07874AF6D5C CRC64;
     TFTAWCNSHL RKAGTQIENI EEDFRNGLKL MLLLEVISGE RLPKPDRGKM RFHKIANVNK
     ALDYIASKGV KLVSIGAEEI VDGNVKMTLG MIWTIILRFA IQDISVEETS AKEGLLLWCQ
     RKTAPYRNVN IQNFHTSWKD GLGLCALIHR HRPDLIDYSK LNKDDPIGNI NLAMEIAEKH
     LDIPKMLDAE DIVNTPKPDE RAIMTYVSCF YHAFAGAEQA ETAANRICKV LAVNQENERL
     MEEYERLASE LLEWIRRTIP WLENRTPEKT MQAMQKKLED FRDYRRKHKP PKVQEKCQLE
     INFNTLQTKL RISNRPAFMP SEGKMVSDIA GAWQRLEQAE KGYEEWLLNE IRRLERLEHL
     AEKFRQKAST HETWAYGKEQ ILLQKDYESA SLTEVRALLR KHEAFESDLA AHQDRVEQIA
     AIAQELNELD YHDAVNVNDR CQKICDQWDR LGTLTQKRRE ALERMEKLLE TIDQLHLEFA
     KRAAPFNNWM EGAMEDLQDM FIVHSIEEIQ SLITAHEQFK ATLPEADGER QSIMAIQNEV
     EKVIQSYSIR ISSSNPYSTV TMDELRTKWD KVKQLVPIRD QSLQEELARQ HANERLRRQF
     AAQANAIGPW IQNKMEEIAR SSIQITGALE DQMNQLKQYE HNIINYKNNI DKLEGDHQLI
     QEALVFDNKH TNYTMEGEAE FARIMTLVDP NGQGTVTFQS FIDFMTRETA DTDTAEQVIA
     SFRILASDKP YILAEELRRE LPPDQAQYCI KRMPAYSGPG SVPGALDYTA FSSALYGESD
     L
//