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Database: UniProt
Entry: A0A2K5HIU8_COLAP
LinkDB: A0A2K5HIU8_COLAP
Original site: A0A2K5HIU8_COLAP 
ID   A0A2K5HIU8_COLAP        Unreviewed;      4920 AA.
AC   A0A2K5HIU8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   05-DEC-2018, entry version 7.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSCANP00000004273};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSCANP00000004273};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000004273, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000004273, ECO:0000313|Proteomes:UP000233080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hughes D.S., Murali S., Raveendran M., Korchina V., Bandaranaike D.,
RA   Bellair M., Blankenburg K., Chao H., Dahdouli M., Dinh H.,
RA   Doddapaneni H., Gnanaolivu R., Gross S., Jayaseelan J., Jones J.,
RA   Khan Z., Kovar C., Kurapati P., Le B., Lee S., Mathew T.,
RA   Narasimhan A., Okwuonu G., Ongeri F., Osuji N., Qu C., Quiroz J.,
RA   Rajbhandari K., Reid J.G., Santibanez J., Skinner E., Wang Y., Xin Y.,
RA   Han Y., Muzny D.M., Richards S., Worley K.C., Rogers J., Gibbs R.A.;
RT   "Black and white colobus reference genome project.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCANP00000004273}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   Ensembl; ENSCANT00000016727; ENSCANP00000004273; ENSCANG00000008910.
DR   GeneTree; ENSGT00940000154906; -.
DR   Proteomes; UP000233080; Whole Genome Shotgun Assembly.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060048; P:cardiac muscle contraction; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010882; P:regulation of cardiac muscle contraction by calcium ion signaling; IEA:Ensembl.
DR   GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000233080};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4242   4261       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4462   4482       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4536   4555       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4660   4678       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4721   4742       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4797   4820       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      107    162       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      169    214       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      222    277       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      283    346       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      348    405       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      596    806       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1022   1219       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1336   1559       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3985   4020       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      469    489       {ECO:0000256|SAM:Coils}.
FT   COILED     3053   3073       {ECO:0000256|SAM:Coils}.
FT   COILED     3318   3338       {ECO:0000256|SAM:Coils}.
FT   COILED     4374   4400       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4920 AA;  558179 MW;  70277DD5FBF026C7 CRC64;
     LKPGGRGGSE LGSCNCTPDD EVVLQCTATI HKEQQKLCLA AEGFGNRLCF LESTSNSKNV
     PPDLSICTFV LEQSLSVRAL QEMLANTVEK SEGQVDVEKW TAQGGGHRTL LYGHAILLRH
     SYSGMYLCCL STSRSSTDKL AFDVGLQEDT TGEACWWTIH PASKQRSEGE KVRVGDDLIL
     VSVSSERYLH LSYGNGSLHV DAAFQQTLWS VAPISSGSEA AQGYLIGGDV LRLLHGHMDE
     CLTVPSGEHG EEQRRTVHYE GGAVSVHARS LWRLETLRVA WSGSHIRWGQ PFRLRHVTTG
     KYLSLMEDKN LLLMDKEKAD VKSTAFTFRS SKEKLDAGVR KEVDGMGTSE IKYGDSVCYI
     QHVDTGLWLT YQSVDVKSVR MGSIQRKAIM HHEGHMDDGI SLSRSQHEES RTARVIRSTV
     FLFNRFIRGL DALSKKAKAS TVDLPIESVS LSLQDLIGYF HPPDEHLEHE DKQNRLRALK
     NRQNLFQEEG MINLVLECID RLHVYSSAAH FADVAGREAG ESWKSILNSL YELLAALIRG
     NRKNCAQFSG SLDWLISRLE RLEASSGILE VLHCVLVESP EALNIIKEGH IKSIISLLDK
     HGRNHKVLDV LCSLCVCHGV AVRSNQHLIC DNLLPGRDLL LQTRLVNHVS SMRPNIFLGV
     SEGSAQYKKW YYELMVDHTE PFVTAEATHL RVGWASTEGY SPYPGGGEEW GGNGVGDDLF
     SYGFDGLHLW SGCIARTVSS PNQHLLRTDD VISCCLDLSA PSISFRINGQ PVQGMFENFN
     IDGLFFPVVS FSAGIKVRFL LGGRHGEFKF LPPPGYAPCY EAVLPKEKLK VEHSREYKQE
     RTYTRDLLGP TVSLTQAAFT PIPVDTSQIV LPPHLERIRE KLAENIHELW VMNKIELGWQ
     YGPVRDDNKR QHPCLVEFSK LPEQERNYNL QMSLETLKTL LALGCHVGIS DEHAEDKVKK
     MKLPKNYQLT SGYKPAPMDL SFIKLTPSQE AMVDKLAENA HNVWARDRIR QGWTYGIQQD
     VKNRRNPRLV PYTLLDDRTK KSNKDSLREA VRTLLGYGYN LEAPDQDHAA RAEVCSGTGE
     RFRIFRAEKT YAVKAGRWYF EFETVTAGDM RVGWSRPGCQ PDQELGSDER AFAFDGFKAQ
     RWHQGNEHYG RSWQAGDVVG CMVDMNEHTM MFTLNGEILL DDSGSELAFK DFDVGDGFIP
     VCSLGVAQVG RMNFGKDVST LKYFTICGLQ EGYEPFAVNT NRDITMWLSK RLPQFLQVPS
     NHEHIEVTRI DGTIDSSPCL KVTQKSFGSQ NSHTDIMFYR LSMPIECAEV FSKTVAGGLP
     GAGLFGPKND LEDYDADSDF EVLMKTAHGH LAPDRVDKDK EATKPEFNNH KDYAQEKPSR
     LKQRFLLRRT KPDYSTSHSA RLTEDVLADD RDDYDFLMQT STYYYSVRIF PGQDPANVWV
     GWITSDFHQY DTGFDLDRVR TVTVTLGDEK GKVHESIKRS NCYMVCAGES MSPGQGRNNN
     GLEIGCVVDA ASGLLTFIAN GKELSTYYQV EPSTKLFPAV FAQATSPNVF QFELGRIKNV
     MPLSAGLFKS EHKNPVPQCP PRLHVQFLSH VLWSRMPNQF LKVDVSRISE RQGWLVQCLD
     PLQFMSLHIP EENRSVDILE LTEQEELLKF HYHTLRLYSA VCALGNHRVA HALCSHVDEP
     QLLYAIENKY MPGLLRAGYY DLLIDIHLSS YATARLMMNN EYIVPMTEET KSITLFPDEN
     KKHGLPGIGL STSLRPRMQF SSPSFVSISN ECYQYSPEFP LDILKAKTIQ MLTEAVKEGS
     LHARDPVGGT TEFLFVPLIK LFYTLLIMGI FHNEDLKHIL QLIEPSVFKE AATPEEESDT
     LEKELSVDDA KLQGAGEEEA KGGKRPKEGL LQMKLPEPVK LQMCLLLQYL CDCQVRHRIE
     AIVAFSDDFV AKLQDNQRFR YNEVMQALNM SAALTARKTK EFRSPPQEQI NMLLNFKDDK
     SECPCPEEIR DQLLDFHEDL MTHCGIELDE DGSLDGNSDL TIRGRLLSLV EKVTYLKKKQ
     AEKPVESDSK KSSTLQQLIS ETMVRWAQES VIEDPELVRA MFVLLHRQYD GIGGLVRALP
     KTYTINGVSV EDTINLLASL GQIRSLLSVR MGKEEEKLMI RGLGDIMNNK VFYQHPNLMR
     ALGMHETVME VMVNVLGGGE SKEITFPKMV ANCCRFLCYF CRISRQNQKA MFDHLSYLLE
     NSSVGLASPA MRGSTPLDVA AASVMDNNEL ALALREPDLE KVVRYLAGCG LQSCQMLVSK
     GYPDIGWNPV EGERYLDFLR FAVFCNGESV EENANVVVRL LIRRPECFGP ALRGEGGNGL
     LAAMEEAIKI AEDPSRDGPS PNSGSSKTLD TEEEEDDTIH MGNAIMTFYA ALIDLLGRCA
     PEMHLIHAGK GEAIRIRSIL RSLIPLGDLV GVISIAFQMP TIAKDGNVVE PDMSAGFCPD
     HKAAMVLFLD RVYGIEVQDF LLHLLEVGFL PDLRAAASLD TVALSATDMA LALNRYLCTA
     VLPLLTRCAP LFAGTEHHAS LIDSLLHTVY RLSKGCSLTK AQRDSIEVCL LSICGQLRPS
     MMQHLLRRLV FDVPLLNEHA KMPLKLLTNH YERCWKYYCL PGGWGNFGAA SEEELHLSRK
     LFWGIFDALS QKKYEQELFK LALPCLSAVA GALPPDYMES NYVSMMEKQS SMDSEGNFNP
     QPVDTSNITI PEKLEYFINK YAEHSHDKWS MDKLANGWIY GEIYSDSSKV QPLMKPYKLL
     SEKEKEIYRW PIKESLKTML AWGWRIERTR EGDSMALYNR TRRISQTSQV SVDAAHGYSP
     RAIDMSNVTL SRDLHAMAEM MAENYHNIWA KKKKMELESK GGGNHPLLVP YDTLTAKEKA
     KDREKAQDIL KFLQINGYAV SRGFKDLELD TPSIEKRFAY SFLQQLIRYV DEAHQYILEF
     DGGSRGKGEH FPYEQEIKFF AKVVLPLIDQ YFKNHRLYFL SAASRPLCSG GHASNKEKEM
     NIEKFSGQFI RHFVSSSGND ATSIVNCLHI LGQTLDARTV MKTGLESVKS ALRAFLDNAA
     EDLEKTMENL KQGQFTHTRN QPKGVTQIIN YTTVALLPML SSLFEHIGQH QFGEDLILED
     VQVSCYRILT SLYALGTSKS IYVERQRSAL GECLAAFAGA FPVAFLETHL DKHNIYSIYN
     TKSSRERAAL SLPTNVEDVC PNIPSLEKLM EEIVELAESG IRYTQMPHVM EVILPMLCSY
     MSRWWEHGPE NNPERAEMCC TALNSEHMNT LLGNILKIIY NNLGIDEGAW MKRLAVFSQP
     IINKVKPQLL KTHFLPLMEK LKKKAAMVVS EEDHLKAEAR GDMSEAELLI LDEFTTLKYL
     YPFLMFLIYQ INTCLLVLTE ISFATSQNFK REEQNFVVQN EINNMSFLIT DTKSKMSKAA
     VSDQERKKMK RKGDRYSMQT SLIVAALKRL LPIGLNICAP GDQELIALAK NRFSLKDTED
     EVRDIIRSNI HLQGKLEDPA IRWQMALYKD LPNRTDDTSD PEKTVERVLD IANVLFHLEQ
     KSKRVGRRHY CLGSTVEHPQ RSKKAVWHKL LSKQRKRAVV ACFRMAPLYN LPRHRAVNLF
     LQGYEKSWIE TEEHYFEDKL IEDLAKPGAE PPEEDEGTKR VDPLHQLILL FSRTALTEKC
     CHDEEDDDGE EEVKSFEEKE MEKQKLLYQQ ARLHDRGAAE MVLQTISASK GETGPMVAAT
     LKLGIAILNG GNSTVQQKML DYLKEKKDVG FFQSLAGLMQ SCSVLDLNAF ERQNKAEGLG
     MVTEEGSGEK VLQDDEFTCD LFRFLQLLCE GHNSDFQNYL RTQTGNNTTV NIIISTVDYL
     LRVQESISDF YWYYSGKDVI DEQGQRNFSK AIQVAKQVFN TLTEYIQGPC TGNQQSLAHS
     RLWDAVVGFL HVFAHMQMKL SQDSSQIELL KELMDLQKDM VVMLLSMLEG NVVNGTIGKQ
     MVDMLVESSN NVEMILKFFD MFLKLKDLTS SDTFKEYDPD GKGVISKRDF HKAMESHKHY
     TQSETEFLLS CAETDENETL DYEEFVKRFH EPAKDIGFNV AVLLTNLSEH MPNDTRLQTF
     LELAESVLNY FQPFLGRIEI MGSAKRIERV YFEISESSRT QWEKPQVKES KRQFIFDVVN
     EGGEKEKMEL FVNFCEDTIF EMQLAAQISE SDLNERSANK EESEKERPEE QGPRMAFFSI
     LTVKSALFAL RYNILTLMRM LSLKSLKKQM KKVKKMTVKD MVTAFFSSYW SIFMTLLHFV
     ASVFRGFFRI ICSLLLGGSL VEGAKKIKVA ELLANMPDPT QDEVRGDGEE GERKPLEAAL
     PSEDLTDLKE LTEESDLLSD IFGLDLKREG GQYKLIPHNP NAGLSDLMSN PVPMPEVQEK
     FQEQKAKEEE KEDKEETKSE PEKAEGEDGE KEEKAKEDKG KQKLRQLHTH RYGEPEVPES
     AFWKKIIAYQ QKLLNYFARN FYNMRMLALF VAFAINFILL FYKVSTSSVV EGKELPTRSS
     SENAKVTSLD SSSHRIIAVH YVLEESSGYM EPTLRILAIL HTVISFFCII GYYCLKVPLV
     IFKREKEVAR KLEFDGLYIT EQPSEDDIKG QWDRLPTKCF FSYPKVMDKY GEFYGRDRIS
     ELLGMDKAAL DFSDAREKKK PKKDSSLSAV LSSIDVKYQM WKLGVVFTDN SFLYLAWYMT
     MSVLGHYNNF FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV VYLYTVVAFN
     FFRKFYNKSE DGDTPDMKCD DMLTCYMFHM YVGVRAGGGI GDEIEDPAGD EYEIYRIIFD
     ITFFFFVIVI LLAIIQGLII DAFGELRDQQ EQVKEDMETK CFICGIGNDY FDTVPHGFET
     HTLQEHNLAN YLFFLMYLIN KDETEHTGQE SYVWKMYQER CWEFFPAGDC FRKQYEDQLN
//
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