ID A0A2K5HJJ1_COLAP Unreviewed; 168 AA.
AC A0A2K5HJJ1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Gremlin {ECO:0000256|PIRNR:PIRNR037254};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000004518.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000004518.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR037254}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872,
CC ECO:0000256|PIRNR:PIRNR037254}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011811068.1; XM_011955678.1.
DR AlphaFoldDB; A0A2K5HJJ1; -.
DR SMR; A0A2K5HJJ1; -.
DR STRING; 336983.ENSCANP00000004518; -.
DR Ensembl; ENSCANT00000017528.1; ENSCANP00000004518.1; ENSCANG00000015684.1.
DR GeneID; 105521477; -.
DR KEGG; cang:105521477; -.
DR CTD; 64388; -.
DR OMA; RRQHLNK; -.
DR OrthoDB; 5347549at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR InterPro; IPR017159; Gremlin-1/2.
DR PANTHER; PTHR15283; GREMLIN 1; 1.
DR PANTHER; PTHR15283:SF2; GREMLIN-2; 1.
DR Pfam; PF03045; DAN; 1.
DR PIRSF; PIRSF037254; Gremlin_precursor; 1.
DR SMART; SM00041; CT; 1.
DR PROSITE; PS01225; CTCK_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|PIRNR:PIRNR037254};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR037254-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR037254};
KW Signal {ECO:0000256|PIRNR:PIRNR037254}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|PIRNR:PIRNR037254"
FT CHAIN 22..168
FT /note="Gremlin"
FT /evidence="ECO:0000256|PIRNR:PIRNR037254"
FT /id="PRO_5014212934"
FT DOMAIN 73..163
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT DISULFID 73..123
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1,
FT ECO:0000256|PROSITE-ProRule:PRU00039"
FT DISULFID 87..137
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
FT DISULFID 97..155
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
FT DISULFID 101..157
FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1"
SQ SEQUENCE 168 AA; 19320 MW; D5A4E4E818BF8C0E CRC64;
MFWKLSLSLF LVAVLVKVAE ARKNRPAGAI PSPYKDGSSN NSERWQHQIK EVLASSQEAL
VVTERKYLKS DWCKTQPLRQ TVSEEGCRSR TILNRFCYGQ CNSFYIPRHV KKEEESFQSC
AFCKPQRVTS VLVELECPGL DPPFRLKKIQ KVKQCRCMSV NLSDSDKQ
//
