ID A0A2K5HKM5_COLAP Unreviewed; 889 AA.
AC A0A2K5HKM5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000259|PROSITE:PS50262};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000004880.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000004880.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A2K5HKM5; -.
DR Ensembl; ENSCANT00000018912.1; ENSCANP00000004880.1; ENSCANG00000016317.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0016500; F:protein-hormone receptor activity; IEA:InterPro.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd15361; 7tmA_LGR4; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002131; Gphrmn_rcpt_fam.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24372; GLYCOPROTEIN HORMONE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 4.
DR PRINTS; PR00373; GLYCHORMONER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM00364; LRR_BAC; 9.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 14.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 477..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 558..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 687..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 722..742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 493..739
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 889 AA; 98543 MW; 55A8CB822B3AB4C9 CRC64;
DISMNNITQL PEDAFKNFPF LEELQLAGND LSFIHPKALS GLKELKVLTL QNNQLKTVPS
EAIRGLSALQ SLRLDANHIT SVPEDSFEGL VQLRHLWLDD NSLTEVPVHP LSNLPTLQAL
TLALNKISSI PDFSFTNLSS LVVLHLHNNK IKSLSQHCFD GLDNLETLDL NYNNLGEFPQ
AIKALPSLKE LGFHSNSISV IPDGAFDGNP LLRTIHLYDN PLSYVGNSAF HNLSDLHSLV
IRGASMVQQF PNLTGTAHLE SLTLTGTKIS SIPNNLCQEQ KMLRTLDLSY NNIRDLPSFN
GCHALEEISL QRNQIYQIKE GTFQGLISLR ILDLSRNLIH EIHSKAFATL GPITNLDVSF
NELTSFPTEG LNGLNQLKLV GNFKLKEALA AKDFVNLRSL SVPYAYQCCA FWGCDSYANL
NTEDNSLQDH NVAQEKGTAD AANVTSTVEN EEHSQIIIHC TPSTGAFKPC EYLLGSWMIR
LTVWFIFLVA LFFNLLVILT TFASCTSLPS SKLFIGLISV SNLFMGIYTG ILTFLDAVTW
GRFAEFGIWW ETGSGCKVAG FLAVFSSESA IFLLMLATFE RSLSAKDVMK NGKSNHLKQF
RVAALLAFLG ATVAGCFPLF HRGEYSASPL CLPFPTGETP SLGFTVTLVL LNSLAFLLMA
IIYTKLYCNL EKEDLSENSQ SSMIKHVAWL IFTNCIFFCP VAFFSFAPLI TAISISPEIM
KSVTLIFFPL PACLNPVLYV FFNPKFKEDW KLLKRRVTKK SGSVSVSISS QGGCLEQDFY
YDCGMYSHLQ GNLTVCDCCE SFLLTKPVSC KHLIKSHSCP ALAVASCQRP EGYWSDCGTQ
SAHSDYADEE DSFVSDSSDQ VQACGRACFY QSRGFPLVRY AYNLPRVKD
//
