ID   A0A2K5HM44_COLAP        Unreviewed;       491 AA.
AC   A0A2K5HM44;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Reduced folate transporter {ECO:0000256|PIRNR:PIRNR028739};
DE   AltName: Full=Solute carrier family 19 member 1 {ECO:0000256|PIRNR:PIRNR028739};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000005409.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000005409.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Transporter that mediates the import of reduced folates.
CC       {ECO:0000256|PIRNR:PIRNR028739}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR028739};
CC       Multi-pass membrane protein {ECO:0000256|PIRNR:PIRNR028739}. Apical
CC       cell membrane {ECO:0000256|PIRNR:PIRNR028739}. Basolateral cell
CC       membrane {ECO:0000256|PIRNR:PIRNR028739}.
CC   -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC       2.A.48) family. {ECO:0000256|ARBA:ARBA00005773,
CC       ECO:0000256|PIRNR:PIRNR028739}.
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DR   AlphaFoldDB; A0A2K5HM44; -.
DR   Ensembl; ENSCANT00000020747.1; ENSCANP00000005409.1; ENSCANG00000018527.1.
DR   OMA; MQFMELF; -.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008518; F:folate:monoatomic anion antiporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005542; F:folic acid binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015350; F:methotrexate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:1904447; P:folate import across plasma membrane; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR002666; Folate_carrier.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR028339; SLC19A1.
DR   NCBIfam; TIGR00806; rfc; 1.
DR   PANTHER; PTHR10686; FOLATE TRANSPORTER; 1.
DR   PANTHER; PTHR10686:SF12; REDUCED FOLATE TRANSPORTER; 1.
DR   Pfam; PF01770; Folate_carrier; 1.
DR   PIRSF; PIRSF028739; Folate_carrier; 1.
DR   PIRSF; PIRSF500793; Folate_transporter_1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|PIRNR:PIRNR028739};
KW   Cell membrane {ECO:0000256|PIRNR:PIRNR028739};
KW   Folate-binding {ECO:0000256|PIRNR:PIRNR028739};
KW   Membrane {ECO:0000256|PIRNR:PIRNR028739, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|PIRNR:PIRNR028739}.
FT   TRANSMEM        68..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        94..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        156..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        184..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        304..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        392..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          468..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   491 AA;  54555 MW;  7EA9989F9884697B CRC64;
     MVPSSPAVEK QVPVEPGPDP ELRSWRRLVC YLCFYGFMAQ IRPGESFITP YLLGPDKNFT
     RKQVTNEITP VLSYSYLAVL VPVFLLTDYL RYTPVLLLQG LSFVSVWLLL LLGHSVAHMQ
     LMELFYSVTM AARIAYSSYI FSLVRPARYQ RVAGYSRAAV LLGVFTSSVL GQLLVTVGRV
     SFSTLNYISL AFLTFSVVLA LFLKRPKRSL FFNRDDRERG EASASELERM NAGPGGKLGR
     ALRAACGDSV LARMLRELGN SLRRPQLRLW SLWWVFNSAG YYLVVYYVHI LWNEVDPTTN
     SARVYNGAAD AASTLLGAIT SFAAGFVKIR WVRWSKLLIA GVTATQAGLV FLLVRTSSIW
     LCYAAFVLFR GSYQFLVPIA TFQIASSLSK ELCALVFGVN TFFATVVKTI ITFIVSDVRG
     LGLPVRKQAL RMSRPDSASA CLVPSHSKVQ PQLEQVLQPP QQRTLVARGD PGGERGPWWR
     EGTVAAKGAR G
//