ID A0A2K5HPM1_COLAP Unreviewed; 2012 AA.
AC A0A2K5HPM1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Dedicator of cytokinesis 3 {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000006285.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000006285.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 336983.ENSCANP00000006285; -.
DR Ensembl; ENSCANT00000023705.1; ENSCANP00000006285.1; ENSCANG00000019037.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08695; C2_Dock-B; 1.
DR CDD; cd11704; DHR2_DOCK3; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037811; C2_Dock-B.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026800; DHR2_DOCK3.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF4; DEDICATOR OF CYTOKINESIS PROTEIN 3; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT DOMAIN 362..540
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1169..1576
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1582..1603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1675..1712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1831..1909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1949..2012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1675..1706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1853..1902
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1963..1987
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2012 AA; 231179 MW; 074D131CE33D862F CRC64;
LNINRKFVCV YIHIYKIITY FNYFSFSFHS FSISLVFHPT PKMPFQKHKV DLFYKLRHVM
NELIDLRRQL LSGHLTQDQV REVKRHITVR LDWGNEHLGL DLVPRKDFEV VDSDQISVSD
LYKMHLSSRQ SVQQSTSQVD TMRPRHGETC RMPVPHHFFL SLKSFTYNTI GEDTDVFFSL
YDMREGKQIS ERFLVRLNKN GGPRNPEKIE RMCALFTDLS SKDMKRDLYI VAHVIRIGRM
LLNDSKKGPP HLHYRRPYGC AVLSILDVLQ SLTEVKEEKD FVLKVYTCNN ESEWSQIHEN
IIRKSSAKYS APSASHGLII SLQLLRGDME QIRRENPMIF NRGLAITRKL GFPDVIMPGD
IRNDLYLTLE KGDFERGGKS VQKNIEVTMY VLYADGEILK DCISLGSGEP NRSSYHSFVL
YHSNSPRWGE IIKLPIPIDR FRGSHLRFEF RHCSTKDKGE KKLFGFAFSP LMRDDGTTLS
DDIHELYVYK CDENSTFNNH ALYLGLPCCK EDYNGCPNIP SSLIFQRSTK ESFFISTQLS
STKLTQNVDL LALLKWKAFP DRIMDVLGRL RHVSGEEIVK FLQDILDTLF VILDDNTEKY
GLLVFQSLVF IINLLRDIKY FHFRPVMDTY IQKHFAGALA YKELIRCLKW YMDCSAELIR
QDHIQEAMRA LEYLFKFIVQ SRILYSRATC GMEEEQFRSS IQELFQSIRF VLSLDSRNSE
TLLFTQAALL NSFPTIFDEL LQMFTVQEVA EFVRGTLGSM PSTVHIGQSM DVVKLQSIAR
TVDSRLFSFS ESRRILLPVV LHHIHLHLRQ QKELLICSGI LGSIFSIVKT SSLEADVMEE
VEMMVESLLD VLLQTLLTIM SKSHAQEAVR GQRCPQCTAE ITGEYVSCLL SLLRQMCDTH
FQHLLDNFQS KDELKEFLLK IFCVFRNLMK MSVFPRDWMV MRLLTSNIIV TTVQYLSSAL
HKNFTETDFD FKVWNSYFSL AVLFINQPSL QLEIITSVKR KKILDKYGDM RVMMAYELFS
MWQNLGEHKI HFIPGMIGPF LGVTLVPQPE VRNIMIPIFH DMMDWEQRKN GNFKQVEAEL
IDKLDSMVSE GKGDESYREL FSLLTQLFGP YPSLLEKVEQ ETWRETGISF VTSVTRLMER
LLDYRDCMKG EETENKKIGC TVNLMNFYKS EINKEEMYIR YIHKLCDMHL QAENYTEAAF
TLLLYCELLQ WEDRPLREFL HYPSQTEWQR KEGLCRKIIH YFNKGKSWEF GIPLCRELAC
QYESLYDYQS LSWIRKMEAS YYDNIMEQQR LEPEFFRVGF YGRKFPFFLR NKEYVCRGHD
YERLEAFQQR MLSEFPQAVA MQHPNHPDDT ILQCDAQYLQ IYAVTPIPDY VDVLQMDRVP
DRVKSFYRVN NVRKFRYDRP FHKGPKDKEN EFKSLWIERT TLTLTHSLPG ISRWFEVERR
ELVEVSPLEN AIQVVENKNQ ELRSLISQYQ HKQVHGNINL LSMCLNGVID AAVNGGIARY
QEAFFDKDYI NKHPGDAEKI TQLKELMQEQ VHVLGVGLAV HEKFVHPEMR PLHKKLIDQF
QMMRASLYHE FPGLDKLSPA CSGTSTPRGN VLASHSPMSP ESIKMTHRHS PMNLMGTGRH
SSSSLSSHAS SEAGNMVMLG DGSMGDAPED LYHHMQLVYP NPRYQGSVTN VSVLSSSQAS
PSSSSLSSTH SAPSQMITSA PSSARGSPSL PDKYRHAREM MLLLPTYRDR PSSAMYPAAI
LENGQPPNFQ RALFQQVVGA CKPCSDPNLS VAEKAVPAAP SSWSLDSGAQ EAQPFLSAHM
GRILAPPVPP RSLLHGHYSL HFDAFHHPLG DTPPALPART LRKSPLHPIP ASPTSPQSGL
DGSNSTLSGS ASSGVSSLSE SNFGHSSEVP PRTDTMDSMP SQAWNADEDL EPPYLPVHYS
LSESAVLDSI KAQPCRSHSA PGCVIPQDPM DPPALPPKPY HPRLPALEHD EGVLLREETE
RPRGLHRKAS LPPGSAKEEQ ARMAWEHGRG EQ
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