ID A0A2K5HQ15_COLAP Unreviewed; 103 AA.
AC A0A2K5HQ15;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Histone H4 {ECO:0000256|ARBA:ARBA00020836, ECO:0000256|RuleBase:RU000528};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000006424.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000006424.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC {ECO:0000256|ARBA:ARBA00002001, ECO:0000256|RuleBase:RU000528}.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA. {ECO:0000256|RuleBase:RU000528}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the histone H4 family.
CC {ECO:0000256|ARBA:ARBA00006564, ECO:0000256|RuleBase:RU000528}.
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DR RefSeq; XP_011800314.1; XM_011944924.1.
DR RefSeq; XP_011800322.1; XM_011944932.1.
DR RefSeq; XP_011800323.1; XM_011944933.1.
DR RefSeq; XP_011800338.1; XM_011944948.1.
DR RefSeq; XP_011809602.1; XM_011954212.1.
DR RefSeq; XP_011809605.1; XM_011954215.1.
DR RefSeq; XP_011818220.1; XM_011962830.1.
DR RefSeq; XP_011818221.1; XM_011962831.1.
DR RefSeq; XP_011818236.1; XM_011962846.1.
DR RefSeq; XP_011818247.1; XM_011962857.1.
DR RefSeq; XP_011818253.1; XM_011962863.1.
DR RefSeq; XP_011818260.1; XM_011962870.1.
DR SMR; A0A2K5HQ15; -.
DR STRING; 336983.ENSCANP00000001569; -.
DR Ensembl; ENSCANT00000006551.1; ENSCANP00000001569.1; ENSCANG00000005886.1.
DR Ensembl; ENSCANT00000009873.1; ENSCANP00000002419.1; ENSCANG00000008897.1.
DR Ensembl; ENSCANT00000012658.1; ENSCANP00000003138.1; ENSCANG00000011422.1.
DR Ensembl; ENSCANT00000012851.1; ENSCANP00000003176.1; ENSCANG00000011479.1.
DR Ensembl; ENSCANT00000013294.1; ENSCANP00000003296.1; ENSCANG00000011891.1.
DR Ensembl; ENSCANT00000013530.1; ENSCANP00000003417.1; ENSCANG00000012166.1.
DR Ensembl; ENSCANT00000015264.1; ENSCANP00000003860.1; ENSCANG00000013613.1.
DR Ensembl; ENSCANT00000017248.1; ENSCANP00000004412.1; ENSCANG00000015446.1.
DR Ensembl; ENSCANT00000017252.1; ENSCANP00000004416.1; ENSCANG00000015454.1.
DR Ensembl; ENSCANT00000022231.1; ENSCANP00000005868.1; ENSCANG00000019756.1.
DR Ensembl; ENSCANT00000023019.1; ENSCANP00000006093.1; ENSCANG00000020469.1.
DR Ensembl; ENSCANT00000024188.1; ENSCANP00000006424.1; ENSCANG00000021491.1.
DR GeneID; 105513874; -.
DR GeneID; 105513882; -.
DR GeneID; 105513883; -.
DR GeneID; 105513905; -.
DR GeneID; 105520452; -.
DR GeneID; 105526736; -.
DR GeneID; 105526737; -.
DR GeneID; 105526740; -.
DR GeneID; 105526748; -.
DR GeneID; 105526752; -.
DR GeneID; 105526757; -.
DR KEGG; cang:105513874; -.
DR KEGG; cang:105513882; -.
DR KEGG; cang:105513883; -.
DR KEGG; cang:105513905; -.
DR KEGG; cang:105520452; -.
DR KEGG; cang:105526736; -.
DR KEGG; cang:105526737; -.
DR KEGG; cang:105526740; -.
DR KEGG; cang:105526748; -.
DR KEGG; cang:105526752; -.
DR KEGG; cang:105526757; -.
DR OrthoDB; 4702965at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR CDD; cd00076; H4; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR001951; Histone_H4.
DR InterPro; IPR019809; Histone_H4_CS.
DR InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom.
DR PANTHER; PTHR10484; HISTONE H4; 1.
DR PANTHER; PTHR10484:SF0; HISTONE H4; 1.
DR Pfam; PF15511; CENP-T_C; 1.
DR PRINTS; PR00623; HISTONEH4.
DR SMART; SM00417; H4; 1.
DR SMART; SM00803; TAF; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR PROSITE; PS00047; HISTONE_H4; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU000528};
KW Citrullination {ECO:0000256|ARBA:ARBA00022934};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000528};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Nucleosome core {ECO:0000256|ARBA:ARBA00023269,
KW ECO:0000256|RuleBase:RU000528};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU000528};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 28..93
FT /note="TATA box binding protein associated factor (TAF)
FT histone-like fold"
FT /evidence="ECO:0000259|SMART:SM00803"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 103 AA; 11367 MW; A9E5DFD3F8B97598 CRC64;
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK
VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG FGG
//
