ID A0A2K5HRG7_COLAP Unreviewed; 821 AA.
AC A0A2K5HRG7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS01186};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000006934.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000006934.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; A0A2K5HRG7; -.
DR Ensembl; ENSCANT00000025988.1; ENSCANP00000006934.1; ENSCANG00000022777.1.
DR OMA; XLNECLH; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 4.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF3; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 8; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 6.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 6.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 6.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 6.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..821
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014328303"
FT TRANSMEM 742..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 277..291
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT DOMAIN 316..331
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 379..425
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 426..468
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 469..512
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 513..557
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 655..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 30..42
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 37..55
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 49..64
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 69..81
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 76..94
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 131..146
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 150..162
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 157..175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 169..184
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 184..202
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 196..211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 216..228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 223..241
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 235..250
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 821 AA; 90320 MW; D74D8060E2C6039D CRC64;
LLLLLLLRLQ HLAAAAADPL LGGQGPAKEC EKDQFQCQNE RCIPSVWRCD EDDDCADHSD
EDDCPKKTCA DSDFTCDNGH CIRERWKCDG EEECPDGSDE SEATCTKQVC PAEKLSCGPT
SHKCVPASWR CDGEKDCEGG ADEAGCATLC APHEFQCGNR SCLAAVFVCD GDDDCGDGSD
ERGCADGECV HLGWRCDGDR DCKDKSDEAD CPLGTCHGNE FQCGDGTCVL AIKRCNQEQD
CPDGSDEAGC LQGLNECLHN NGGCSHICTD LKIGFECTCP AGFQLLDQKT CGDIDECKDP
DACSQICVNY KGYFKCECYP GYEMDLLTKN CKAAAGKSPS LIFTNRHEVR RIDLVKRNYS
RLIPMLKNVV ALDVEVATNR IYWCDLSYRK IYSAYMDKAS DPKEQEVLID EQLHSPEGLA
VDWVHKHIYW TDSGNKTISV ATVDGGRRCT LFSRNLSEPR AIAVDPLRGF MYWSDWGNQA
KIEKSGLNGV DRQTLVSDNI EWPNGITLDL LSQRLYWVDS KLHQLSSIDF SGGNRKMLIS
STDFLSHPFG IAVFEDKVFW TDLENEAIFS ANRLNGLEIS ILAENLNNPH DIVIFHELKQ
PRAADACKLS VQPNGGCEYL CLPAPQISSH SPNYTCACPD TMWLGPDMKR CYRAPQSTST
TTLASTTTRT GPATTRAPGT TVHRSTDQNH STETPNLAAA VPSSVSVPRA PSISLSTLSP
ATSNHSQHYG NEDSKMGSTV TAAVIGIIVP IVVIALLCMS GYLIWRNWKR KNTKSMNFDN
PVYRKTTEEE DEDELHIGRT AQIGHVYPAR VALSLEDDGL P
//
