ID A0A2K5HRI5_COLAP Unreviewed; 235 AA.
AC A0A2K5HRI5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Phosphoinositide-3-kinase-interacting protein 1 {ECO:0000256|ARBA:ARBA00044176};
DE AltName: Full=Kringle domain-containing protein HGFL {ECO:0000256|ARBA:ARBA00044210};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000006955.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000006955.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Negative regulator of hepatic phosphatidylinositol 3-kinase
CC (PI3K) activity. {ECO:0000256|ARBA:ARBA00043894}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR AlphaFoldDB; A0A2K5HRI5; -.
DR Ensembl; ENSCANT00000026049.1; ENSCANP00000006955.1; ENSCANG00000023063.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00108; KR; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR PANTHER; PTHR24261:SF16; PHOSPHOINOSITIDE-3-KINASE-INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR24261; PLASMINOGEN-RELATED; 1.
DR Pfam; PF00051; Kringle; 1.
DR SMART; SM00130; KR; 1.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR PROSITE; PS00021; KRINGLE_1; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..235
FT /note="Phosphoinositide-3-kinase-interacting protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014373713"
FT TRANSMEM 169..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..101
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
SQ SEQUENCE 235 AA; 25597 MW; 18B8D70A64A57AB0 CRC64;
MPLAWVQAFL VSNMLLAEAY GSGGCFWDNG HLYREDQTSP APGLRCLNWL DAQSGLTSAP
VSGAGNHSYC RNPDKDPRGP WCYVSGEAGV PEKRPCEDLR CPETISQALP TSTTEIEEAS
EGPGVDEMRV FAPANTLPAR SEAAAVQPVI GISQRVRMNS KEKKDLGTLG YVLGITMMVI
IIAIGAGIIL GYSYKRSVAS LLGPLERRRG GRYTKSNFVA FFPKRKQDVE NQLKM
//
