ID   A0A2K5HRQ3_COLAP        Unreviewed;       327 AA.
AC   A0A2K5HRQ3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=ArfGAP with dual PH domains 2 {ECO:0008006|Google:ProtNLM};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000007027.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000007027.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5HRQ3; -.
DR   STRING; 336983.ENSCANP00000007027; -.
DR   Ensembl; ENSCANT00000026232.1; ENSCANP00000007027.1; ENSCANG00000023260.1.
DR   OMA; RDSKGFQ; -.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:1902936; F:phosphatidylinositol bisphosphate binding; IEA:InterPro.
DR   CDD; cd13252; PH1_ADAP; 1.
DR   CDD; cd01251; PH2_ADAP; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR037849; PH1_ADAP.
DR   InterPro; IPR037851; PH2_ADAP.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR46021; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN; 1.
DR   PANTHER; PTHR46021:SF6; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 2.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          1..105
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   DOMAIN          201..307
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
SQ   SEQUENCE   327 AA;  38247 MW;  315E5052F690A23D CRC64;
     PDWASYKLGI FICLNCCGVH RNFPDISRVK SVRLDFWDDS IVEVAVVLQF MTHNGNLRVK
     AKFEARVPAF YYIPQANDCL VLKEQWIRAK YERREFMADG ETISLPGNRE GFLWKRGRDN
     SQFLRRRFVL LAREGLLKYY TKEGGKSPKA VISIKDLNAT FQTEKIGHPH GLQITYRRDG
     HIRNLFVYHE SGKLVPFLTR NYLKQGFMEK TGPKQREPFK KRWFALDCHE RRLLYYKNPL
     DAFEQGQVFL GNKEQGYEVY EDLPKGIRGN RWKAGLTIVT PERRYVLTCP NEKEQQEWLE
     SLRGVLSSPL TLLNRLTAST ESGRSSR
//