ID A0A2K5HS99_COLAP Unreviewed; 445 AA.
AC A0A2K5HS99;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000007222.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000007222.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-
CC glutamyl-tRNA(Glu); Xref=Rhea:RHEA:23540, Rhea:RHEA-COMP:9663,
CC Rhea:RHEA-COMP:9680, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78520,
CC ChEBI:CHEBI:456215; EC=6.1.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00001818};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC Glutamate--tRNA ligase type 2 subfamily.
CC {ECO:0000256|ARBA:ARBA00008927}.
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DR AlphaFoldDB; A0A2K5HS99; -.
DR Ensembl; ENSCANT00000026816.1; ENSCANP00000007222.1; ENSCANG00000022575.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0004812; F:aminoacyl-tRNA ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006418; P:tRNA aminoacylation for protein translation; IEA:InterPro.
DR CDD; cd10309; GST_C_GluProRS_N; 1.
DR Gene3D; 1.20.1050.130; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR000924; Glu/Gln-tRNA-synth.
DR InterPro; IPR020058; Glu/Gln-tRNA-synth_Ib_cat-dom.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR43097:SF5; GLUTAMATE--TRNA LIGASE; 1.
DR PANTHER; PTHR43097; GLUTAMINE-TRNA LIGASE; 1.
DR Pfam; PF00043; GST_C; 1.
DR Pfam; PF00749; tRNA-synt_1c; 1.
DR PRINTS; PR00987; TRNASYNTHGLU.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363037};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363037};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363037};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363037};
KW Protein biosynthesis {ECO:0000256|RuleBase:RU363037};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT DOMAIN 111..161
FT /note="Glutathione S-transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00043"
FT DOMAIN 206..441
FT /note="Glutamyl/glutaminyl-tRNA synthetase class Ib
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00749"
SQ SEQUENCE 445 AA; 50736 MW; A08D0648F02F55F1 CRC64;
MGFLHVGQAG LELPTSGDPP ASASQTLLAV EHVKDDVSIS IEEGKENILR VSENVIFTDV
NSILRYLARV ATTAGLYGCN LMEHTEIDHW LEFSATKLSS CDSFTSAINE LNHCLSLRTY
LVGNSLSLAD LCVWATLKGN ASWQEQLKQN KAPVHVKRWF GFLEAQQAFQ SVGTKWDVST
TKARVAPEKK QDVGKFVELP GAEMGKVTVR FPPEASGYLH IGHAKAALLN QHYQVNFKGK
LIMRFDDTNP EKEKEDFEKV ILEDVAMLHI KPDQFTYTSD HFETIMKYAE KLIQEGKAYV
DDTPAEQMKA EREQRIESKH RKNPIEKNLQ MWEEMKKGSP FGQSCCLRAK IDMSSNNGCM
RDPTLYRCKI QPHPRTGNKY NVYPTYDFAC PIVDSIEGVT HALRTTEYHD RDEQFYWIIE
ALGIRKPYIW EYSRAIQKKT HMVCQ
//
