ID A0A2K5HSS6_COLAP Unreviewed; 973 AA.
AC A0A2K5HSS6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Roc domain-containing protein {ECO:0000259|PROSITE:PS51424};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000007393.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000007393.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5HSS6; -.
DR STRING; 336983.ENSCANP00000007393; -.
DR Ensembl; ENSCANT00000027401.1; ENSCANP00000007393.1; ENSCANG00000024285.1.
DR OMA; IVCPKNG; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020859; ROC_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF39; MALIGNANT FIBROUS HISTIOCYTOMA-AMPLIFIED SEQUENCE 1 HOMOLOG; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 10.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 11.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF82615; Polo-box domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS51424; ROC; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 324..570
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
SQ SEQUENCE 973 AA; 108717 MW; F7D807A5A5C310A8 CRC64;
EGLGSALGSL RVLVLRRNRF ARLPPAVAEL GHHLTELDVS HNRLTALGAE VVSALRELRK
LNLSHNQLPV LPAQLGALAH LEELDVSFNR LTHLPDSLSC LSRLRTLDVD HNQLTAFPRQ
LLQLAALEEL DVSSNRLRGL PEDISALCAL KILWLSGAEL GTLPAGFCEL ASLESLMLDN
NGLQALPAQF SRLQRLKMLN LSSNLLEEFP AALLPLAGLE ELYLSRNQLT SVPSLISGLG
RLLTLWLDNN RIRYLPDSIV ELTGLEELVL QGNQIAVLPD NFGQLSRVGL WKIKDNPLIQ
PPYEVCMKGI PYIAAYQKEL AHSQPAVQPR LKLLLMGHKA AGKTLLRHCL TEERVEGCPG
GGDKEKCYPP SPPPVSKGIE VTSWTADASR GLRFIVYDLA GDESYEVIQP FFLSPGALYV
LVVNLATYEP RRFPTTVGSF LHRVGARVPH AVVCIVGTHA DLCGERELEE KCLDIHRQIA
LQEKHDAEGL SRLAQVVDEA LARDFELRSA SPHAAYYGVS DKNLRRRKAH FQYLLNHRLQ
ILSPVLPVSC RDPRHLQRLR DKLLSVAEHR EIFPNLHRVL PRSWQVLEEL HFQPPQAQRL
WLSWWDSARL GLQAGLTEDR LQSALSYLHE SGKLLYFEDS PALKEHVFHN LTRLIDILNV
FFQRDPSLLL HKLLLGTSGE GKAEGESSRP VALPTPSQEL LRATQLHQYV EGFLLHGLLP
AHVIRLLLKP HVQAQQDLQL LLELLEKMGL CYCLNKPKGK PLNGSTAWYK FPCYVQNEVP
HAEAWINGTN LAGQSFVAEQ LQIEYSFPFT FPPGLFARYS VQINSHVVHR SDGKFQIFAY
RGKVPVVVSY RPAKGVLQPD TLSIASHASL PNIWTAWQAI TPLVEELNVL LQEWPGLHYT
VHILCSKCLK RGSPNPHAFP GELLSQPRPE GVAEIICPKN GSERVNVALV YPPTPTVISP
CSKKNVGEKH RNQ
//
