ID   A0A2K5HU58_COLAP        Unreviewed;       624 AA.
AC   A0A2K5HU58;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Mitogen-activated protein kinase kinase kinase 3 {ECO:0008006|Google:ProtNLM};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000007870.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000007870.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5HU58; -.
DR   Ensembl; ENSCANT00000029215.1; ENSCANP00000007870.1; ENSCANG00000024863.1.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd06405; PB1_Mekk2_3; 1.
DR   CDD; cd06625; STKc_MEKK3_like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000270; PB1_dom.
DR   InterPro; IPR034879; PB1_MEKK2/3.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   PANTHER; PTHR48016; MAP KINASE KINASE KINASE SSK2-RELATED-RELATED; 1.
DR   PANTHER; PTHR48016:SF50; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19; 1.
DR   Pfam; PF00564; PB1; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00666; PB1; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51745; PB1; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT   DOMAIN          42..121
FT                   /note="PB1"
FT                   /evidence="ECO:0000259|PROSITE:PS51745"
FT   DOMAIN          360..620
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          144..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          216..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..251
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   624 AA;  70625 MW;  310DD18CF798DC50 CRC64;
     EQEALNSIMN DLVALQMNRR HRMPGYETMK NKDTGHSNRQ SDVRIKFEHN GERRIIAFSR
     PVKYEDVEHK VTTVFGQPLD LHYMNNELSI LLKNQDDLDK AIDILDRSSS MKSLRILLLS
     QDRNHNSSSP HSGVSRQVRI KASQSAGDIN TIYQPPEPRS RHLSVSSQNP GRSSPPPGYV
     PERQQHIARQ GSYTSINSEG EFIPETSEQC MLDPLSSAEN SLSGSCQSLD RSADSPSFRK
     SRMSRAQSFP DNRQEYSDRE TQLYDKGVKG GTYPRRYHVS VHHKDYSDGR RTFPRIRRHQ
     GNLFTLVPSS RSLSTNGENM GLAVQYLDPR GRLRSADSEN ALSVQERNVA TKSPSAPINW
     RRGKLLGQGA FGRVYLCYDV DTGRELASKQ VQFDPDSPET SKEVSALECE IQLLKNLQHE
     RIVQYYGCLR DRAEKTLTIF MEYMPGGSVK DQLKAYGALT ESVTRKYTRQ ILEGMSYLHS
     NMIVHRDIKG ANILRDSAGN VKLGDFGASK RLQTICMSGT GMRSVTGTPY WMSPEVISGE
     GYGRKADVWS LGCTVVEMLT EKPPWAEYEA MAAIFKIATQ PTNPQLPSHI SEHGRDFLRR
     IFVEARQRPS AEELLTHHFA QLMY
//