ID   A0A2K5HVQ6_COLAP        Unreviewed;       454 AA.
AC   A0A2K5HVQ6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Syntrophin beta 1 {ECO:0008006|Google:ProtNLM};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000008458.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000008458.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the syntrophin family.
CC       {ECO:0000256|ARBA:ARBA00010798}.
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DR   AlphaFoldDB; A0A2K5HVQ6; -.
DR   STRING; 336983.ENSCANP00000008458; -.
DR   Ensembl; ENSCANT00000031314.1; ENSCANP00000008458.1; ENSCANG00000027630.1.
DR   OMA; RAETCKD; -.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   CDD; cd00821; PH; 1.
DR   CDD; cd01258; PHsplit_syntrophin; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR041428; PHsplit_syntrophin.
DR   InterPro; IPR015482; Syntrophin.
DR   PANTHER; PTHR10554:SF11; BETA-1-SYNTROPHIN; 1.
DR   PANTHER; PTHR10554; SYNTROPHIN; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF18012; PH_17; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00233; PH; 2.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT   DOMAIN          28..111
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          238..349
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          121..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..150
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   454 AA;  50068 MW;  A7AA13748BDE6B6B CRC64;
     PDSPAGVRTA FTDLPEQVPE SISNQKRGVK VLKQELGGLG ISIKGGKENK MPILISKIFK
     GLAADQTQAL YVGDAILSVN GADLRDATHD EAVQALKRAG KEVLLEVKYM REATPYVKKG
     SPVSEIGWET PPPESPRLGG NTSEPLSSQS FSFHRDRKSI PLKMCYVTRS MALADPENRQ
     LEIHSPDAKH TVILRSKDSA TAQAWFSAIH SNVNDLLTQV IAEVREQLGK TGIAGSREIR
     HLGWLAEKVP GESEKQWKPA LVVLTEKDLL IYDSMPRRKE AWFSPVHTYP LLATRLVHSG
     PGKGSPQAGV DLSFATRTGT RQGIETHLFR AETSRDLSHW TRSIVQGCHN SAELIAEIST
     ACTYKNQECR LTIHYENGFS ITTEPQEGAF PKTIIQSPYE KLKMSSDDGI RMLYLDFGGK
     DGEIQLDLHS CPKPIVFIIH SFLSAKITRL GLVA
//