ID A0A2K5HW86_COLAP Unreviewed; 901 AA.
AC A0A2K5HW86;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=RHD domain-containing protein {ECO:0000259|PROSITE:PS50254};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000008561.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000008561.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011806746.1; XM_011951356.1.
DR AlphaFoldDB; A0A2K5HW86; -.
DR Ensembl; ENSCANT00000031426.1; ENSCANP00000008561.1; ENSCANG00000027692.1.
DR GeneID; 105518380; -.
DR CTD; 4773; -.
DR OrthoDB; 5405363at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07881; RHD-n_NFAT; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF4; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT DOMAIN 372..554
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 21..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 901 AA; 97662 MW; BBB4126112766C0A CRC64;
MQREAAFRLG HCHPLRIMGS VDQEEPNAHK VASPPSGPAY PDDVLDYGLK PYSPLASLSG
EPPGRFGEPD RVGPQNFLSA AKPAGASGLS PRIEITPSHE LIQAVGPLRM RDAGLLVEQP
PLAGVAASPR FTLPVPGFEG YREPLCLSPA SSGSSASFIS DTFSPYTSPC VSPNNGGPDD
LCPQFQNIPA HYSPRTSPIM SPRTSLAEDS CLGRHSPVPR PASRSSSPGA KRRHSCAEAL
VALPPGASPQ RSRSPSPQPS SHVAPQDHGA PAGYPPVAGS AVIMDALNSL ATDSPCGIPP
KMWKTSPDPS PVSAAPSKAG LPRHIYPAVE FLGPCEQGER RNSAPESILL VPPTWPKPLV
PAIPICSIPV TASLPPLEWP LSSQSGSYEL RIEVQPKPHH RAHYETEGSR GAVKAPTGGH
PVVQLHGYME NKPLGLQIFI GTADERILKP HAFYQVHRIT GKTVTTTSYE KIVGNTKVLE
IPLEPKNNMR ATIDCAGILK LRNADIELRK GETDIGRKNT RVRLVFRVHI PESSGRIVSL
QTASNPIECS QRSAHELPMV ERQDTDSCLV YGGQQMILTG QNFTAESKVV FTEKTTDGQQ
IWEMEATVDK DKSQPNMLFV EIPEYRNKHI RTPVKVNFYV INGKRKRSQP QHFTYHPVPA
IKTEPTDEYD PTLICSPTHG GLGSQPYYPQ HPMVAESPSC LVATMAPCQQ FRTGLSSPDA
RYQQQNPAAV LYQRSKSLSP SLLGYQQPAL MASPLSLADA HRSVLVHAGS QGQSSALLHP
SPTNQQASPV IHYSPTNQQL RCGSHQEFQH IMYCENFAPG TTRPGPPPVS QGQRLSPGSY
PTVIQQQNAT SQRAAKNGPP VSDQKEVLPA GVTIKQEQNL DQTYLDDELI DTHLSWIQNI
L
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