ID A0A2K5HY18_COLAP Unreviewed; 803 AA.
AC A0A2K5HY18;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Prominin 1 {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000009202.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000009202.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the prominin family.
CC {ECO:0000256|ARBA:ARBA00006058}.
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DR AlphaFoldDB; A0A2K5HY18; -.
DR Ensembl; ENSCANT00000032071.1; ENSCANP00000009202.1; ENSCANG00000027842.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008795; Prominin.
DR PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR PANTHER; PTHR22730:SF3; PROMININ-1; 1.
DR Pfam; PF05478; Prominin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..803
FT /note="Prominin 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014386427"
FT TRANSMEM 102..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 253..283
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 803 AA; 89843 MW; D474BC09F98E0622 CRC64;
MALVLGSLLL LGLCGNSFSG GQPSSTDAPK AWNYELPATN YETQDSHTAG PIGILFELVH
IFLYVVQPRD FPEDTLRKVI QKARESKIDY DKPENLILGL KIVYYEAGII LCSVLGLLFI
ILMPLVGYFF CMCRCCNKCG GEMHQRQKEN GPFLRKCFAI SLLVICIIIS IGIFCGFVAN
HQVRTRIKRS RKLADSNFKD LRTLLNETPE QIKYILAQYN TTKDKAFSDL NSINSVLGGG
ILDRLRPNII PVLDEIKSMA TAIKETKEAL ENMNSTLKSL HQQSTQLSSS LTSVKTSLRA
SLNDPLCSVR PSSETCNSIR LSLSQLNSNP ELRQLPPVDA ELDKVNNVLR TDLDGLVQQG
YQSLNDVPNR VQSQTKTVVA GIKRVLNSIG SDINNVTQRL PIQDILSEFS VYVNNTESCI
HRNLPTLEEY DSYWWLGGLV ICSLLTLIVI FYYLGLLCGV CGYDRHATPT TRGCVSNTGG
VFLMVGVGLS FLFCWILMII VVLTFVFGAN VEKLICEPYT SKELFRVLDT PYLLNEDWEY
YLSGKLFNKS KMKLTFEQVY SDCKKNRGTY GTLHLQNSFN ISECLNINEH TTSISSELES
LKVNLNIFLL GAAGRKNLQD FAACGIDRMN YDTYLAQTGK SPAGVNLLSF AYDLEAKANS
LPPGNLRNSL KRDAQTIKTI HQQRVLPIEQ SLSTLYQSVK ILQRTGNGLL ERVNRILASL
DFAQNFITNN ISSVIIEETK KYGKTIIGYF EHYLQWIEFS ISEKVASCKP VATALDTAVD
VFLCSYIIDP LVETIPMKNP SQH
//
