ID A0A2K5I0R1_COLAP Unreviewed; 1115 AA.
AC A0A2K5I0R1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Nuclear transcription factor, X-box binding 1 {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000010142.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000010142.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NFX1 family.
CC {ECO:0000256|ARBA:ARBA00007269}.
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DR AlphaFoldDB; A0A2K5I0R1; -.
DR STRING; 336983.ENSCANP00000010142; -.
DR Ensembl; ENSCANT00000033028.1; ENSCANP00000010142.1; ENSCANG00000028364.1.
DR OMA; PRTSCED; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06008; NF-X1-zinc-finger; 4.
DR CDD; cd02643; R3H_NF-X1; 1.
DR CDD; cd16696; RING-CH-C4HC3_NFX1; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR034078; NFX1_fam.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR034076; R3H_NF-X1.
DR InterPro; IPR000967; Znf_NFX1.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12360; NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1; 1.
DR PANTHER; PTHR12360:SF12; TRANSCRIPTIONAL REPRESSOR NF-X1; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF01422; zf-NF-X1; 7.
DR SMART; SM00393; R3H; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00438; ZnF_NFX; 7.
DR SUPFAM; SSF82708; R3H domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 355..411
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 358..409
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 989..1057
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT REGION 22..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1076..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1115 AA; 123475 MW; 1D6BCE7BA83F6C3F CRC64;
MAEAPPVSGT FKFNTDAAEF IPQEKKNSGL NCGTQRRLDS NRIGRRNYSS PPPCHLSRQV
PYDEISAVHQ HSYHPSGSKP KSQLTSFQSS PYNKSPKSHG LQSQPWQKLR NEKHHIRVKK
AQSLAEQTSD TAGLESSTRS ESGTDLREHS PSESEKEVVG ADPRGAKPKK ATQFVYSYGR
GPKVKGKLKC EWSNRATPKP EDIGPENTKP VGVFHPDSSD ASSRKGVLDG YGARRNEQRR
YPQKRPPWEV EGARPRPGRN PPKQEGHRHA NTGHRNNMGP IPKDNVSERP AKSTCDSENL
AVINKSSRRV DQEKCTVRRQ DPQVVSPFPR GKQNHVLKNV ETHTGSLIEQ LTTEKYECMV
CCELVRVTAP VWSCQSCYHV FHLNCIKKWA RSPASQADGQ SGWRCPACQN VSAHVPNTYT
CFCGKVKNPE WSRNEIPHSC GEVCRKKQPG QDCPHSCNLL CHPGPCPPCP AFMTKTCECG
RTRHTVRCGQ AVSVHCSNPC ENILNCGQHQ CAELCHGGQC QPCQIILNQV CYCGSTSRDV
LCGTDVGKSD GFGDFSCLKI CGKDLKCGNH TCSQVCHPQP CQPCPRLPPL VRCCPCGQTP
LSQLLELGSS GRKTCMDPVP SCGKVCGKPL PCGSLDFIHT CEKLCHEGDC GPCSRTSVIS
CRCSFRTKEL PCTSLKSEDA TFMCDKRCNK KRLCGRHKCN EICCVVSGLI RHNRIPFIQG
LGFWKPEGAT LRGSCQGFDE LTCHCGASVI YPPVPCGTRP PECTQTCARV HECDHPVYHS
CHSEEKCPPC TFLTQKWCMG KHEFRSNIPC HLVDISCGLP CSATLPCGMH KCQRLCHKGE
CLVDEACKQP CTTPRADCGH PCMAPCHTSS PCAVTACKAK VELQCECGRR KEMVICSEAS
STYQRIAAIS MASKITDMQL GGSVEISKLI TKKEVHQARL ECDEECSALE RKKRLAEAFH
ISEDSDPFNI RSSGSKFSDS LKEDARKDLK FVSDVEKEME TLVEAVNKGK NSKKSHSFPP
MNRDHRRIIH DLAQVYGLES VSYDSEPKRN VVITAVRGKS ICPPTTLTGV LEREMQARPP
PPIPHHRHQS DKNPGSSNLQ KITKEPIIDY FDVQD
//
