ID A0A2K5I2B8_COLAP Unreviewed; 104 AA.
AC A0A2K5I2B8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Gastrin {ECO:0000256|ARBA:ARBA00018558};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000010780.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000010780.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and secrete
CC hydrochloric acid and the pancreas to secrete its digestive enzymes. It
CC also stimulates smooth muscle contraction and increases blood
CC circulation and water secretion in the stomach and intestine.
CC {ECO:0000256|ARBA:ARBA00003187}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU004362}.
CC -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC {ECO:0000256|ARBA:ARBA00006273, ECO:0000256|RuleBase:RU004362}.
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DR RefSeq; XP_011785147.1; XM_011929757.1.
DR AlphaFoldDB; A0A2K5I2B8; -.
DR STRING; 336983.ENSCANP00000010780; -.
DR Ensembl; ENSCANT00000033672.1; ENSCANP00000010780.1; ENSCANG00000028797.1.
DR GeneID; 105503032; -.
DR KEGG; cang:105503032; -.
DR CTD; 2520; -.
DR OMA; WKPRSQL; -.
DR OrthoDB; 5344034at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR InterPro; IPR039236; GAST.
DR InterPro; IPR001651; Gastrin/CCK.
DR InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR PANTHER; PTHR19309; GASTRIN; 1.
DR PANTHER; PTHR19309:SF0; GASTRIN; 1.
DR Pfam; PF00918; Gastrin; 1.
DR SMART; SM00029; GASTRIN; 1.
DR PROSITE; PS00259; GASTRIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..104
FT /note="Gastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014467266"
FT DOMAIN 87..100
FT /note="Gastrin/cholecystokinin peptide hormone"
FT /evidence="ECO:0000259|Pfam:PF00918"
FT REGION 22..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 104 AA; 11782 MW; 7291100631240C57 CRC64;
MQQLCVYALI FALALAAFSE ASWKPRSQQP DAPLGTGANR NLELPWLDQQ GPVFHHRRQL
GPQGPPHLVA DPSKKQGPWM EEEEEAYGWM DFGRRSAEDE NQQP
//
