ID A0A2K5I448_COLAP Unreviewed; 227 AA.
AC A0A2K5I448;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Calcium-activated potassium channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE Short=BKbeta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=BK channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Calcium-activated potassium channel, subfamily M subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Charybdotoxin receptor subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=K(VCA)beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Maxi K channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE AltName: Full=Slo-beta {ECO:0000256|RuleBase:RU368097};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000011326.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000011326.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1
CC (maxiK) channel. Modulates the calcium sensitivity and gating kinetics
CC of KCNMA1, thereby contributing to KCNMA1 channel diversity.
CC {ECO:0000256|RuleBase:RU368097}.
CC -!- SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4 molecules
CC of KCMNB per KCNMA1 tetramer. {ECO:0000256|RuleBase:RU368097}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU368097}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU368097}.
CC -!- PTM: N-glycosylated. {ECO:0000256|RuleBase:RU368097}.
CC -!- SIMILARITY: Belongs to the KCNMB (TC 8.A.14.1) family.
CC {ECO:0000256|RuleBase:RU368097}.
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DR AlphaFoldDB; A0A2K5I448; -.
DR Ensembl; ENSCANT00000034223.1; ENSCANP00000011326.1; ENSCANG00000029061.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0015269; F:calcium-activated potassium channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005513; P:detection of calcium ion; IEA:UniProtKB-UniRule.
DR Gene3D; 4.10.81.20; KCNMB2, ball/chain domain; 1.
DR InterPro; IPR003930; K_chnl_Ca-activ_BK_bsu.
DR InterPro; IPR037096; KCNMB2_ball/chain_dom_sf.
DR InterPro; IPR015382; KCNMB2_ball_chain_dom.
DR PANTHER; PTHR10258; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA; 1.
DR PANTHER; PTHR10258:SF5; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-2; 1.
DR Pfam; PF03185; CaKB; 1.
DR Pfam; PF09303; KcnmB2_inactiv; 1.
DR PRINTS; PR01450; BKCHANNELB.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|RuleBase:RU368097};
KW Ion channel {ECO:0000256|RuleBase:RU368097};
KW Ion transport {ECO:0000256|RuleBase:RU368097};
KW Membrane {ECO:0000256|RuleBase:RU368097};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Transmembrane {ECO:0000256|RuleBase:RU368097};
KW Transmembrane helix {ECO:0000256|RuleBase:RU368097};
KW Transport {ECO:0000256|RuleBase:RU368097}.
FT TRANSMEM 39..62
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368097"
FT TRANSMEM 192..217
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368097"
FT DOMAIN 1..32
FT /note="KCNMB2 ball/chain"
FT /evidence="ECO:0000259|Pfam:PF09303"
SQ SEQUENCE 227 AA; 26360 MW; 3A7DA58F76F0284D CRC64;
MFIWTSGRTS SSYRHDEKRN IYQKIRDHDL LDKRKTDRAI LLGLAMMVCS IMMYFLLGIT
LLRSYMQSVW TEESQCTLLN ASITETFNCS FSCGPDCWKL SQYPCLQVYV NLTSSGEKLL
LYHTEETIKI NQKCSYIPKC GKNFEESMSL VNVVMENFRK YQHFSCYSDP EGNQKSVILT
KLYSSNVLFH SLFWPTCMMA GGVAIVAMVK LTQYLSLLCE RIQRINR
//