ID A0A2K5I8V8_COLAP Unreviewed; 396 AA.
AC A0A2K5I8V8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Bone morphogenetic protein 2 {ECO:0000256|ARBA:ARBA00035684};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000012981.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000012981.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_011796396.1; XM_011941006.1.
DR AlphaFoldDB; A0A2K5I8V8; -.
DR STRING; 336983.ENSCANP00000012981; -.
DR Ensembl; ENSCANT00000035893.1; ENSCANP00000012981.1; ENSCANG00000029900.1.
DR GeneID; 105511004; -.
DR KEGG; cang:105511004; -.
DR CTD; 650; -.
DR OMA; AVMRWIA; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR CDD; cd19390; TGF_beta_BMP2; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR047953; BMP2_TGF_beta-like.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF143; BONE MORPHOGENETIC PROTEIN 2; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Chondrogenesis {ECO:0000256|ARBA:ARBA00023188};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..396
FT /note="Bone morphogenetic protein 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014396328"
FT DOMAIN 279..396
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 84..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..293
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 396 AA; 44744 MW; 9323B221F83E9C4C CRC64;
MVAGTRCLLA LLLPQVLLGG AAGLVPELGR RKFAASSSGR PSSQPSDEVL SEFELRLLSM
FGLKQRPTPS RDAVVPPYML DLYRRQSGQP GSPAPDHRLE RAASRANTVR SFHHEESLEE
LPEMSGKTTR RFFFNLSSIP TEEFITSAEL QVFREQMQDA LGDNSSFHHR INIYEIIKPA
TANSKFPMTR LLDTRLVNQN ASRWESFDVT PAVMRWTAQG HANHGFVVEV THLEEKQGVS
KRHVRISRSL HQGEHSWSQI RPLLVTFGHD GKGHPLHKRE KRQAKHKQRK RLKSSCKRHP
LYVDFSDVGW NDWIVAPPGY HAFYCHGECP FPLADHLNST NHAIVQTLVN SVNSKIPKAC
CVPTELSAIS MLYLDENEKV VLKNYQDMVV EGCGCR
//
