ID A0A2K5I9W0_COLAP Unreviewed; 928 AA.
AC A0A2K5I9W0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Proprotein convertase subtilisin/kexin type 6 {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000013428.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000013428.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR AlphaFoldDB; A0A2K5I9W0; -.
DR STRING; 336983.ENSCANP00000013428; -.
DR Ensembl; ENSCANT00000036342.1; ENSCANP00000013428.1; ENSCANG00000030011.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 4.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR PANTHER; PTHR42884:SF8; PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 6; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00261; FU; 5.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 454..594
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT DOMAIN 890..928
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT REGION 617..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 164
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 205
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 379
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 928 AA; 102956 MW; 1D454B58DF5B3D81 CRC64;
VSTGAEPAPG VDSVRGHSQA AATQDVQAAE IIWDFVFRPF WKLFVRLLID GILLLVLQIG
NLEDYYHFYH SKTFKRSTLS SRGPHTFLRM DPQVKWLQQQ EVKRRVKRQV RSDPQALYFN
DPIWSNMWYL HCGDKNSRCR SEMNVQAAWK RGYTGKNVVV TILDDGIERN HPDLAPNYDS
YASYDVNGND YDPSPRYDAS NENKHGTRCA GEVAASANNS YCIVGIAYNA KIGGIRMLDG
DVTDVVEAKS LGIRPNYIDI YSASWGPDDD GKTVDGPGRL AKQAFEYGIK KGRQGLGSIF
VWASGNGGRE GDYCSCDGYT NSIYTISVSS ATENGYKPWY LEECASTLAT TYSSGAFYER
KIVTTDLRQR CTDGHTGTSV SAPMVAGIIA LALEANGQLT WRDVQHLLVK TSRPAHLKAS
DWKVNGAGHK VSHFYGFGLV DAEALVVEAK KWTAVPSQHM CVAASDKRPR SIPLVQVLRT
TALTSACAEH SDQRVVYLEH VVVRISISHP RRGDLQIYLI SPSGTKSQLL AKRLLDLSNE
GFTNWEFMTV HCWGEKAEGQ WTLEIQDLPS QVRNPEKQGK LKEWSLILYG TAEHPYHTFS
AHQSRSRMLE LSAPELEPPK AALSPSQVEV PEDEEDYTAH STPGSANILQ TSVCHPECGD
KGCDGPNADQ CLNCIHFSLG SVKTSRKCVS VCPLGYFGDT AARRCRRCHK GCETCSGRGA
TQCLSCRRGF YHHQEMNTCV TLCPAGFYAD ESQKNCLKCH PSCKKCVDEP EKCTVCKEGF
SLARGSCIPD CEPGTYFDSE LIRCGECHHT CGTCVGPGRE ECIHCAKNFH FQDWKCVPAC
GEGFYPEEMP GLPHKVCRRC DENCLSCAGS SRNCSRCKTG FTQLGTSCIT NHTCSNADET
FCEMVKSNRL CERKLFIQFC CRTCLLAG
//
