ID   A0A2K5IA40_COLAP        Unreviewed;       905 AA.
AC   A0A2K5IA40;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 {ECO:0008006|Google:ProtNLM};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000013518.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000013518.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5IA40; -.
DR   STRING; 336983.ENSCANP00000013518; -.
DR   Ensembl; ENSCANT00000036432.1; ENSCANP00000013518.1; ENSCANG00000030146.1.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005925; C:focal adhesion; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016477; P:cell migration; IEA:InterPro.
DR   CDD; cd17900; ArfGap_ASAP3; 1.
DR   CDD; cd07640; BAR_ASAP3; 1.
DR   CDD; cd13251; PH_ASAP; 1.
DR   Gene3D; 1.25.40.950; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR043593; ASAP.
DR   InterPro; IPR047006; ASAP3_ArfGap.
DR   InterPro; IPR028775; BAR_ASAP3.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR037844; PH_ASAP.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR45854:SF1; ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR   PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF16746; BAR_3; 1.
DR   Pfam; PF00169; PH; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW   ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          304..396
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          428..553
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   REPEAT          623..655
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          742..905
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          146..173
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        778..809
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        891..905
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   905 AA;  98997 MW;  9C8B46CDEF6F5397 CRC64;
     SGLTAALTSP GSGDPPTSAS QVAGTIGRCH HMEMGFWQVV QAGLEILEGD QAILQRIKKA
     VRAIHSSGLG HVENEEQYRE AVESLGNSHL SQNSHELSTG FLNLAVFTRE VAALFKNLIQ
     NLNNIVSFPL DSLMKGQLRD GRQDSKKQLE KAWKDYETKM AKLEKERDRA RVTGGIPGEV
     AQDTQRERRI FQLHMCEYLL KAGESQMKQG PDFLQSLIKF FHAQHNFFQD GWKAAQSLFP
     FIEKLAASVH ALHQAQEEEL QKLTQLRDSL RGTLQLESRE EHLSRKNSGC GYSIHQHQGN
     KQFGTEKVGF LYKKSDGIRR VWQKRKCGVK YGCLTISHST INRPPVKLTL LTCQVRPNPE
     EKKCFDLVTH NRTYHFQAED EHECEAWVSV LQNSKDEALS SAFLGEPSGG LGSWGAAGHD
     GEPHDLTKLL IAEVKSRPGN SQCCDCGAAD PTWLSTNLGV LTCIQCSGVH RELGVRFSRM
     QSLTLDLLGP SELLLALNMG NTSFNEVMEA QLPSHGGPKP SAESDMGTRR DYIVAKYVEH
     RFARRCTPEP RRLWTAICNR DLLSVLEAFA NGQDFGQPLP GPDAQAPEEL ALHLAIKVAS
     QASLPLVDFI IQNGGHLDAK AADGNTALHY AALYNQPDCL KLLLKGRALV GTVNEAGETA
     LDIARKKHHK ECEELLEQAQ AGTLAFPLHV AYSWVISTEP GFDSEEDEEE KRCLLKLPVQ
     AHWASGRLDI SNKTYETVTS LGAATPQGES EDCPPPLPVK NSSRTVVQGC ARHASGDHSE
     VSSLSSEAPE TPESLGSPAS SSSLMSPVGP GGPSQAPPNS EEGLREPPGT SRPSLTSGTT
     PLEVYLPVRF SSESTRSYRR GARSPEDGPS ARQPLPRRNM PVGVTEGDGS RTGSLPASSV
     QLLQD
//