ID   A0A2K5IA62_COLAP        Unreviewed;       851 AA.
AC   A0A2K5IA62;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 {ECO:0008006|Google:ProtNLM};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000013529.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000013529.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5IA62; -.
DR   Ensembl; ENSCANT00000036443.1; ENSCANP00000013529.1; ENSCANG00000030146.1.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005925; C:focal adhesion; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016477; P:cell migration; IEA:InterPro.
DR   CDD; cd17900; ArfGap_ASAP3; 1.
DR   CDD; cd07640; BAR_ASAP3; 1.
DR   CDD; cd13251; PH_ASAP; 1.
DR   Gene3D; 1.25.40.950; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR043593; ASAP.
DR   InterPro; IPR047006; ASAP3_ArfGap.
DR   InterPro; IPR028775; BAR_ASAP3.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR037844; PH_ASAP.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR45854:SF1; ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR   PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF16746; BAR_3; 1.
DR   Pfam; PF00169; PH; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW   ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          250..342
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          374..499
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   REPEAT          569..601
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          688..851
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        724..755
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        837..851
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   851 AA;  93136 MW;  2E1E48AC5E645E6E CRC64;
     ILEGDQAILQ RIKKAVRAIH SSGLGHVENE EQYREAVESL GNSHLSQNSH ELSTGFLNLA
     VFTREVAALF KNLIQNLNNI VSFPLDSLMK GQLRDGRQAS LSLGSRAKLE KERDRARVTG
     GIPGEVAQDT QRERRIFQLH MCEYLLKAGE SQMKQGPDFL QSLIKFFHAQ HNFFQDGWKA
     AQSLFPFIEK LAASVHALHQ AQEEELQKLT QLRDSLRGTL QLESREEHLS RKNSGCGYSI
     HQHQGNKQFG TEKVGFLYKK SDGIRRVWQK RKCGVKYGCL TISHSTINRP PVKLTLLTCQ
     VRPNPEEKKC FDLVTHNRTY HFQAEDEHEC EAWVSVLQNS KDEALSSAFL GEPSGGLGSW
     GAAGHDGEPH DLTKLLIAEV KSRPGNSQCC DCGAADPTWL STNLGVLTCI QCSGVHRELG
     VRFSRMQSLT LDLLGPSELL LALNMGNTSF NEVMEAQLPS HGGPKPSAES DMGTRRDYIV
     AKYVEHRFAR RCTPEPRRLW TAICNRDLLS VLEAFANGQD FGQPLPGPDA QAPEELALHL
     AIKVASQASL PLVDFIIQNG GHLDAKAADG NTALHYAALY NQPDCLKLLL KGRALVGTVN
     EAGETALDIA RKKHHKECEE LLEQAQAGTL AFPLHVAYSW VISTEPGFDS EEDEEEKRCL
     LKLPVQAHWA SGRLDISNKT YETVTSLGAA TPQGESEDCP PPLPVKNSSR TVVQGCARHA
     SGDHSEVSSL SSEAPETPES LGSPASSSSL MSPVGPGGPS QAPPNSEEGL REPPGTSRPS
     LTSGTTPLEV YLPVRFSSES TRSYRRGARS PEDGPSARQP LPRRNMPVGV TEGDGSRTGS
     LPASSVQLLQ D
//