ID A0A2K5IB29_COLAP Unreviewed; 884 AA.
AC A0A2K5IB29;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000013853.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000013853.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR AlphaFoldDB; A0A2K5IB29; -.
DR Ensembl; ENSCANT00000036772.1; ENSCANP00000013853.1; ENSCANG00000030143.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF15; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 48..143
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 258..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 815..842
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 297..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 884 AA; 101040 MW; AECEC5C7B1AC2194 CRC64;
NYIPIKNLKI IIKINSPSRH LTSTFLLEQD SWEVVEGLRG EMNYTQEPPV QKGFLLKKRK
WPLKGWHKRF FYLDKGILKY AKSQTDIERE KLHGCIDVGL SVMSVKKSSK CIDLDTEEHI
YHLKVKSEEV FDEWVSKLRH HRMYRQNEIA MFPHEVNHFF SGSTTADSAS GVFDSISSRK
RSSISKQNLF QTGSNVSFSC GGETRVPLWL QSSEDMEKCF KDLAHCHAYL VEMSQLLQSM
DVLHRTYSAP AINAIQGGAF ESPKKEKRPQ RRWRSRAIGK DAKGTLQVPK PFSGPVRLHS
SNPNLSTLDF GEEKNYSDGS ETSSEFSKMQ EDLCHIAHKV YFTLRSAFNI MSAEREKLKQ
LMEQDASSSP SAQVIGLKNA LSSALAQNTD LKERLRRIHA ESLLLDSPAV AKSGDNLAEE
NSRDENRALV HQLSNESRLS ITDSLSEFFD AQEVLLSPSS SENEISEDDS YVSDISDNLS
LDNLSNDLDN ERQTLGPVLE SGGEAKSQRR TCLPAPCPSS SNISLWNILR NNIGKDLSKV
AMPVELNEPL NTLQRLCEEL EYSELLDKAA QIPSPLERMV YVAAFAISAY ASSYYRAGSK
PFNPVLGETY ECIREDKGFQ FFSEQVSHHP PISACHAESR NFVFWQDVRW KNKFWGKSME
IVPIGTTHVT LPAFGDHFEW NKVTSCIHNI LSGQRWIEHY GEIVIKNLND DSCYCKVNFI
KAKYWSTNAH EIEGTVFDRS GNAVHRLFGK WHESIYCGGS SSSACVWRAN PMPKGYEQYY
GFTQFALELN EMDLSSKSLL PPTDTRFRPD QRFLEEGNLE EAEIQKQRIE QLQRERRRVL
EENHVEHQPR FFRKSNDDSW LSNGTYLELR KDLGFSKLDH PVLW
//
