ID A0A2K5ID15_COLAP Unreviewed; 335 AA.
AC A0A2K5ID15;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Syntaxin-18 {ECO:0000256|ARBA:ARBA00019409};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000014539.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000014539.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Syntaxin that may be involved in targeting and fusion of
CC Golgi-derived retrograde transport vesicles with the ER.
CC {ECO:0000256|ARBA:ARBA00003746}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004163}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004163}. Membrane
CC {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004211}.
CC -!- SIMILARITY: Belongs to the syntaxin family.
CC {ECO:0000256|ARBA:ARBA00009063}.
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DR RefSeq; XP_011790818.1; XM_011935428.1.
DR AlphaFoldDB; A0A2K5ID15; -.
DR Ensembl; ENSCANT00000037468.1; ENSCANP00000014539.1; ENSCANG00000030653.1.
DR GeneID; 105507067; -.
DR KEGG; cang:105507067; -.
DR CTD; 53407; -.
DR OMA; PVNLWEE; -.
DR OrthoDB; 3032483at2759; -.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005484; F:SNAP receptor activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR CDD; cd15850; SNARE_syntaxin18; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR InterPro; IPR019529; Syntaxin-18_N.
DR InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR PANTHER; PTHR15959; SYNTAXIN-18; 1.
DR PANTHER; PTHR15959:SF0; SYNTAXIN-18; 1.
DR Pfam; PF10496; Syntaxin-18_N; 1.
DR SUPFAM; SSF58038; SNARE fusion complex; 1.
DR PROSITE; PS00914; SYNTAXIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 312..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..96
FT /note="SNARE-complex protein Syntaxin-18 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10496"
FT REGION 168..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 335 AA; 38645 MW; D8A6C7AD9CAC5977 CRC64;
MAVDITLLFR ASVKTVKTRN KALGVALGGG VDGSRDELFR RSPRPKGDFS SRAREVISHI
GKLRDFLLEH RKDYINAYSN TMSEYGRMTD TERDQIDQDA QIFMRTCSEA IQQLRTEAHK
EIHSQQVKEH RTAVLDFIED YLKRVCKLYS EQRAIRVKRV VDKKRLSKLE PEPNTKTRES
TSSEKVSQSP SKDSEENPAT EEHPEKILAE TQPELGTWGD GKGEDELSPE EIQMFEQENQ
RLIGEMNSLF DEVRQIEGRV VEISRLQEIF TEKVLQQEAE IDSIHQLVVG ATENIKEGNE
DIREAIKNNA GFRVWILFFL VMCSFSLLFL DWYDS
//
