ID   A0A2K5IHB4_COLAP        Unreviewed;       176 AA.
AC   A0A2K5IHB4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=PYD and CARD domain containing {ECO:0008006|Google:ProtNLM};
OS   Colobus angolensis palliatus (Peters' Angolan colobus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Colobus.
OX   NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000016068.1, ECO:0000313|Proteomes:UP000233080};
RN   [1] {ECO:0000313|Ensembl:ENSCANP00000016068.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Inflammasome {ECO:0000256|ARBA:ARBA00004110}.
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DR   RefSeq; XP_011789024.1; XM_011933634.1.
DR   AlphaFoldDB; A0A2K5IHB4; -.
DR   Ensembl; ENSCANT00000039004.1; ENSCANP00000016068.1; ENSCANG00000031474.1.
DR   GeneID; 105505708; -.
DR   CTD; 29108; -.
DR   OrthoDB; 4179218at2759; -.
DR   Proteomes; UP000233080; Unplaced.
DR   GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd08330; CARD_ASC_NALP1; 1.
DR   CDD; cd08321; Pyrin_ASC-like; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   PANTHER; PTHR46985:SF2; APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD; 1.
DR   PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; DEATH domain; 2.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS50824; DAPIN; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00023233};
KW   Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT   DOMAIN          1..91
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          88..176
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
SQ   SEQUENCE   176 AA;  19978 MW;  68D6C7CDC7990E76 CRC64;
     MGRARDAILD ALENLTAEEL KKFKLKLLSV PLREGYGRIP RGALLSMDAL DLTDKLVSFY
     LETYGAELTA NVLRDMGMQE MAGQLQAATH QGLHFIDQHR AALITRVTDV EGLLDALYGK
     VLKDEQYQEV RAESTNPSKM RKLFSFTPAW NWTCKDLLLQ ALRETQSYLV EDLERS
//