ID A0A2K5IHP0_COLAP Unreviewed; 1140 AA.
AC A0A2K5IHP0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=DAB2 interacting protein {ECO:0008006|Google:ProtNLM};
OS Colobus angolensis palliatus (Peters' Angolan colobus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Colobinae; Colobus.
OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000016130.1, ECO:0000313|Proteomes:UP000233080};
RN [1] {ECO:0000313|Ensembl:ENSCANP00000016130.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5IHP0; -.
DR Ensembl; ENSCANT00000039066.1; ENSCANP00000016130.1; ENSCANG00000031370.1.
DR Proteomes; UP000233080; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF26; DISABLED HOMOLOG 2-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000233080}.
FT DOMAIN 119..153
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 144..262
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 322..514
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1115..1140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1082..1109
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 19..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..66
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..866
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..886
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..986
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1140 AA; 125320 MW; C33E606F4CD507E1 CRC64;
VMGDSLLEGG ESPQERPGSR RSLPGSLSEK SPSMEPSAAT PFRVTVTISA SPPPPLPPPS
PPRPGCCSAT PRSHLMPRLK ESRSHESLLS PSSAVEALDL SMEEEVVIKP VHSSILGQDY
CFEVTTSSGS KCFSCRSAAE RDKWMENLRR AVHPNKDNSR RVEHILKLWV IEAKDLPAKK
KYLCELCLDD VLYARTTGKL KTDNVFWGEH FEFHNLPPLR TVTVHLYRET DKKKKKERNS
YLGLVSLPAA SVAGRQFVEK WYPVVTPNPK GGKGPGPMIR IKARYQTITI LPMEMYKEFA
EHITNHYLGL CAALEPILSA KTKEEMASAL VHILQSTGKV KDFLTDLMMS EVDRCGDNEH
LIFRENTLAT KAIEEYLKLV GQKYLQDALG EFIKALYESD ENCEVDPSKC SAADLPEHQG
NLKMCCELAF CKIINSYCVF PRELKEVFAS WRQECSSRGR PDISERLISA SLFLRFLCPA
IMSPSLFNLL QEYPDDRTAR TLTLIAKVTQ NLANFAKFGS KEEYMSFMNQ FLEHEWTNMQ
RFLLEISNPE TLSNTAGFEG YIDLGRELSS LHSLLWEAIS QLEQSIVSKL GPLPRILRDV
HTALSTPGSG QLPGTNDLAS TPGSGSSSIS AGLQKMVIEN DLSGLIDFTR LPSPTPENKD
LFFVTRSSGV QPSPARSSSY SEANEPDLQM ANSGKSLSMV DLQDARALDG EAGSPAGPDV
LPTDGQAPAA QLVAGWPARA TPVSLAGLAT VRRAGQTPTT PGTSEGAPGR PQLLAPLSFQ
NPVYQMAAGL PLSPRGLGDS GSEGHSSLSS HSNSEELAAA AKLGSFSTAA EELARRPGEL
ARRQMSLTEK GGQPTVPRQN SAGPQRRIDQ PPPPPPPPPP APRGRTPPNL LGTLQYPRPS
SGTLASASPD WAGPSTRLRQ QSSSSKGDSP ELKPRSVHKQ GPSPVSPNAL DRTAAWLLTM
NAQLLEDEGL GPDPPHRDRL RSKDELSQAE KDLAVLQDKL RISTKKLEEY ETLFKCQEET
TQKLVLEYQA RLEEGEERLR RQQEDKDIQM KGIISRLMSV EEELKKDHAE MQAAVDSKQK
IIDAQEKRIA SLDAANARLM SALTQLKERY SMQARNGISP TNPTKLQITE NGEFRNSSNC
//
